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Schizophrenia

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Featured Genetics Neuroscience Psychology

·May 15, 2023·5 min read

Schizophrenia Risk Genes: Placenta’s Role May Outweigh Brain’s

In a paradigm shift, researchers found over 100 genes associated with schizophrenia risk operate primarily through their role in the placenta, rather than the developing brain. The research emphasizes the placenta's significance in illness development, challenging the century-old assumption that genes for schizophrenia risk primarily affect the brain.

Featured Neuroscience Psychology

·May 12, 2023·7 min read

Synaptic Clues Blur Line Between Schizophrenia and Bipolar Disorder

Researchers found compelling molecular evidence suggesting that bipolar disorder and schizophrenia, traditionally viewed as distinct conditions, may have more similarities than previously thought. By examining thousands of proteins present at synapses in the brains of patients with each disorder, they found changes that were remarkably alike. The team also discovered similar biochemical alterations in mice with a mutated gene linked to both conditions. The study reveals the shared molecular roots of these conditions and points to the synapse as a critical area of study for psychiatric disorders.

Featured Neuroscience Psychology

·May 6, 2023·7 min read

Cannabis Use Disorder Linked to Increased Schizophrenia Risk in Males

A new study finds that young men with cannabis use disorder are at an increased risk of developing schizophrenia. The study, which analyzed health records data of more than 6 million people in Denmark, estimated that up to 30% of schizophrenia cases among young men aged 21-30 might have been prevented by avoiding cannabis use disorder, highlighting the need for preventative measures and treatments for cannabis use disorder and schizophrenia.

Featured Neuroscience Psychology

·April 29, 2023·4 min read

Schizophrenia Identified in 60 Seconds via Visual Fixation

Researchers have identified spatial and temporal abnormalities in spontaneous fixational saccades as a potential biomarker for cognitive and positive symptoms in schizophrenia. Researchers combined patient data of fixational eye movement recorded over 60 seconds with machine learning technology, which was able to determine schizophrenia with 85% accuracy. This discovery suggests that fixational saccades could serve as an easily obtainable complementary diagnostic tool for the condition.

Featured Neuroscience Neuroscience Videos

·April 29, 2023·5 min read

Cognitive Flexibility: How the Brain Learns New Rules to Navigate the Changing World

In everyday life, our brains adapt to new situations using the prefrontal cortex. A team of neuroscientists discovered a special class of neurons in the prefrontal cortex that enable flexible behavior, and when malfunctioning, may contribute to conditions like schizophrenia and bipolar disorder. These long-range inhibitory connections synchronize gamma oscillations across the left and right prefrontal cortex, allowing the brain to change its behavior at the right moment. This research could lead to new treatments for psychiatric conditions by targeting these long-range inhibitory connections.

Featured Genetics Neuroscience Psychology

·April 27, 2023·5 min read

Identification of DNA Methylation Markers in Newborns for Increased Schizophrenia Risk

Researchers identified DNA methylation markers that may indicate the risk of developing schizophrenia later in life in newborns. This breakthrough discovery could allow for early detection and intervention to reduce the impact of the disease. By studying blood samples collected at birth, the team was able to identify unique methylation differences in cell types that could become potential clinical biomarkers for future early detection of schizophrenia.

Featured Neuroscience Psychology

·April 14, 2023·5 min read

Disrupted Rhythms of Rest and Wakefulness Contribute to Worse Symptoms in Schizophrenia Patients

Those with schizophrenia who had more erratic sleep patterns, excessively rigid daily routines, and dysregulated patterns between sleep and wake transition had worse symptoms associated with schizophrenia and poorer quality of life.

Featured Genetics Neuroscience Psychology

·March 13, 2023·3 min read

Novel Genes That May Increase Risk for Schizophrenia Identified

A new study has identified two novel genes associated with schizophrenia, and a third new gene linked to an increased risk of autism and schizophrenia.

Featured Neuroscience Psychology

·March 6, 2023·4 min read

Pregnant Women With Schizophrenia Have Threefold Risk of Interpersonal Violence

Pregnant women and new mothers with schizophrenia are three times more likely to visit the emergency room as a result of being victims of interpersonal violence, a new study finds.

Featured Neuroscience Psychology

·February 17, 2023·3 min read

Vasodilator Drug Used in Stroke Patients Found to Reverse Key Symptoms of Schizophrenia

Vasodilators such as fasudil, commonly used for the treatment of stroke, restored pyramidal neurons in the prefrontal cortex of mouse models of schizophrenia associated with genetics.

Featured Genetics Neuroscience Psychology

·February 7, 2023·4 min read

Potential Therapeutic Target for Schizophrenia Identified

Calcium signaling was found to be a central abnormality in schizophrenia neurons. Targeting calcium signaling in neurons could be a potential new way to treat the 16p11.2 duplication variation of schizophrenia.

Featured Genetics Neuroscience Open Neuroscience Articles Psychology

·January 24, 2023·3 min read

Abnormal 12-Hour Cyclic Gene Activity Found in Schizophrenic Brains

Postmortem brains of those with schizophrenia have fewer genes associated with 12-hour activity cycles in the dorsolateral prefrontal cortex. Mitochondrial-related genes in the dlPFC did maintain a 12-hour rhythm, but their activity did not peak at normal times.

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Schizophrenia

Schizophrenia Risk Genes: Placenta’s Role May Outweigh Brain’s

Synaptic Clues Blur Line Between Schizophrenia and Bipolar Disorder

Cannabis Use Disorder Linked to Increased Schizophrenia Risk in Males

Schizophrenia Identified in 60 Seconds via Visual Fixation

Cognitive Flexibility: How the Brain Learns New Rules to Navigate the Changing World

Identification of DNA Methylation Markers in Newborns for Increased Schizophrenia Risk

Disrupted Rhythms of Rest and Wakefulness Contribute to Worse Symptoms in Schizophrenia Patients

Novel Genes That May Increase Risk for Schizophrenia Identified

Pregnant Women With Schizophrenia Have Threefold Risk of Interpersonal Violence

Vasodilator Drug Used in Stroke Patients Found to Reverse Key Symptoms of Schizophrenia

Potential Therapeutic Target for Schizophrenia Identified

Abnormal 12-Hour Cyclic Gene Activity Found in Schizophrenic Brains

Young Adult Substance Use Affects Memory at 65

Nicotine Vapes Outperform Patches and Gum for Quitters

Split Protein Builds the Infrastructure for Weight Loss

Can Deep Brain Stimulation Unlock Treatment-Resistant Depression?

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