Deterioration in hearing and persistent tinnitus may be another feature of COVID-19 infection, researchers report. A significant number of patients reported hearing loss and other auditory problems eight weeks after being discharged from hospital for coronavirus. Researchers say it is possible COVID-19 could damage parts of the auditory system, resulting in hearing loss.
Children younger than five with mild-to-moderate coronavirus have might higher levels of genetic materials for the virus in their noses compared to older children and adults. The findings suggest young children as able to transmit COVID-19 to the same degree as those in other age groups.
Study identifies the TLR7 gene as an essential player in the immune response against coronavirus infection.
Study reveals mutations of SARS-CoV-2, the virus that causes COVID-19, may not be a random process, but instead, humans are mutating it as part of a defense mechanism to degrade the virus. The findings may help in the creation of a vaccine for coronavirus.
Infection of non-neuronal supporting cells in the nose and forebrain may be responsible for the olfactory problems associated with COVID-19. Findings suggest olfactory sensory neurons are not vulnerable to coronavirus infection as they do not express ACE2.
A COVID-19 vaccine under trial in the UK is safe, has few side effects, and induces a strong immune response in both parts of the immune system within 14 days of administration.
Coronavirus infection can lead to an array of neurological complications, including delirium, stroke, and a rare, often fatal neuroinflammatory condition called ADEM. The neurological complications did not always correlate with the severity of respiratory symptoms. In some patients, brain inflammation was likely caused by an immune response to COVID-19, suggesting the neurological damage may be a result of immune system activation rather than the virus itself.
Study supports the link between chilblains, or COVID-toes, and coronavirus infection. Researchers report endothelial damage induced by COVID-19 infection could be the key mechanism causing the lesions.
A new study highlights the most common neurological and psychological complications that arise as a result of coronavirus infection. The most common brain complication was stroke, reported in 77 of 125 patients studied. Of those, 57 patients had a stroke caused by a blood clot in the brain. Behavioral changes, confusion, and altered mental state were also reported in a significant number of patients. Depression and anxiety were also commonly reported. Ten patients developed psychosis as a result of COVID-19, and six developed a dementia-like syndrome.
Cholesterol-lowering statins show promise for the treatment of severe coronavirus infections. Statins lowered the death rate and decreased the need for mechanical ventilation in patients hospitalized for severe COVID-19.
Some coronavirus patients exhibit clinical and neurochemical signs of brain injury associated with the viral infection. COVID-19 patients who required ventilation had increased plasma NfL levels. The higher NfL concentration levels were linked to the severity of infection.
Dexamethasone, an inexpensive steroid, reduced death by one-third in ventilated COVID-19 patients, and by one fifth in patients receiving oxygen for severe coronavirus symptoms. Preliminary findings suggest one death per eight patients ventilated could be prevented by administering dexamethasone.