In rheumatoid arthritis, inflammation in one joint is transmitted to other joints via the sensory neuron connections in the spinal cord, leading to inflammation in the other joints. Inflammation in one joint led to an increase in ATP in other joints, which triggered an increase of a signaling molecule that resulted in inflammation. Blocking the pathway reduced the spread of inflammation.
Non-invasive vagus nerve stimulation reduces inflammation and improves symptoms for those suffering from rheumatoid arthritis. The simulation technique helps inhibit the production of cytokines and reduces inflammatory response.
Researchers have identified a genetic overlap between rheumatoid arthritis and Huntington's disease. The findings could open the door to developing new therapeutic targets and medications to combat both conditions.