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          psychopharmacology

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          FeaturedNeurosciencePsychology
          ·November 13, 2024·6 min read

          Schizophrenia Risks Tied to Psychedelic Use

          A new study links hallucinogen-related emergency department visits to a 21-fold increased risk of schizophrenia compared to the general population. Even after accounting for other mental health disorders and substance use, individuals faced a 3.5-fold higher risk.
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          FeaturedNeurosciencePsychology
          ·November 13, 2024·4 min read

          Psychedelic Therapy Could Benefit 5.6 Million People with Depression

          Psilocybin-assisted therapy could potentially benefit up to 5.6 million Americans with major depressive disorder or treatment-resistant depression, offering a powerful alternative to traditional treatments. Researchers applied medical criteria to a national pool of patients and found that over half might be eligible for psilocybin therapy, pending FDA approval. If approved, this therapy could significantly impact public health policies, insurance frameworks, and economic costs by reducing reliance on long-term antidepressant prescriptions.
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          This shows a woman and psychedelic swirls.
          FeaturedNeurosciencePsychology
          ·October 3, 2024·4 min read

          Psychedelics Reduce Anxiety Without Hallucinations

          New research has pinpointed the specific brain region and neuron type responsible for reducing anxiety using the psychedelic drug DOI, without triggering hallucinations. The study revealed that DOI targets serotonin2A receptors on parvalbumin-positive neurons in the ventral hippocampus, decreasing anxiety behaviors in animal models.
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          FeaturedNeurosciencePsychology
          ·September 24, 2024·3 min read

          Psychedelic Drug Reduces Anxiety by Targeting Fast-spiking Interneurons

          The psychedelic DOI, a compound similar to LSD, reduced anxiety in mice by activating specific brain cells called fast-spiking interneurons. These neurons silence nearby cells in the ventral hippocampus, a region linked to emotion and memory. By uncovering this mechanism, the study opens the door to designing new treatments that target anxiety without triggering hallucinations, a hallmark of many psychedelics.
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          FeaturedNeurosciencePsychology
          ·September 24, 2024·4 min read

          Anti-inflammatory Drug Boosts Motivation in Depression

          A new study reveals that infliximab, an anti-inflammatory drug, can improve motivation in patients with depression and high inflammation. Researchers found that patients receiving infliximab showed greater effort in reward-based tasks, correlating with changes in brain activity in key motivation regions.
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          FeaturedNeurosciencePsychology
          ·September 24, 2024·2 min read

          Psilocybin Shows Promise in Treating Body Dysmorphic Disorder

          A new study reveals that psilocybin, the active compound in magic mushrooms, may help treat body dysmorphic disorder (BDD) by altering brain connectivity. In a pilot trial, patients with BDD showed significant improvements in symptoms after a single dose of psilocybin, with brain scans indicating increased neural flexibility. Though preliminary, the study suggests that psilocybin could offer new hope for BDD sufferers. Larger studies are needed to confirm its efficacy.
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          This shows a head and psychedelic swirls.
          FeaturedNeurosciencePsychology
          ·September 22, 2024·7 min read

          Psilocybin Shows Greater Long-Term Benefits Over SSRI for Depression

          A study comparing psilocybin to the SSRI escitalopram found both drugs improved depressive symptoms similarly over six months, but psilocybin offered additional psychosocial benefits. Patients taking psilocybin reported a greater sense of meaning, psychological connectedness, and improved social functioning. These results suggest psilocybin could provide a more holistic treatment option for depression, addressing both symptoms and overall well-being. While promising, psilocybin remains experimental and is only administered in controlled environments.
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          This shows pills and a head.
          FeaturedNeurosciencePsychology
          ·September 12, 2024·4 min read

          High Doses of ADHD Meds Linked to Increased Psychosis Risk

          Adults taking high doses of amphetamine-based medications for ADHD, such as Adderall, face a five-fold increased risk of developing psychosis or mania. The risk was highest for those taking 30 mg or more of dextroamphetamine, with 81% of psychosis or mania cases potentially avoidable by lowering the dose.
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          This shows a depressed woman.
          FeaturedNeurosciencePsychology
          ·August 23, 2024·5 min read

          Knowingly Taking Placebos Reduces Stress and Anxiety

          Researchers have discovered that nondeceptive placebos—placebos given with the full knowledge that they are placebos—can effectively manage stress, even when administered remotely. In a two-week randomized controlled trial, participants experiencing prolonged stress were divided into two groups: one group received nondeceptive placebos, while the other served as a control.
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          FeaturedNeurosciencePsychology
          ·August 21, 2024·3 min read

          High-Dose Psilocybin Shows Potential as an Antidepressant Treatment

          A meta-analysis suggests that high doses of psilocybin may alleviate depressive symptoms similarly to the SSRI drug escitalopram. While the effect size was small, psilocybin outperformed placebo in clinical trials, though study design flaws could have led to overestimated results. The findings indicate that psilocybin, particularly in high doses, may offer a new avenue for treating depression, comparable to existing antidepressants.
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          This shows a stressed woman.
          FeaturedNeurosciencePsychology
          ·July 31, 2024·5 min read

          Cannabigerol (CBG) Reduces Anxiety and Improves Memory

          A new study shows that Cannabigerol (CBG) significantly reduces anxiety without the intoxicating effects of THC. The clinical trial found that 20 mg of CBG reduced anxiety and stress in participants, with memory enhancement as an unexpected benefit. The study highlights CBG’s potential as an alternative anxiety treatment. Further research is needed to confirm these findings and explore additional benefits.
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          This shows a psychedelic brain.
          FeaturedNeurosciencePsychology
          ·July 17, 2024·5 min read

          Mind-Bending: Psilocybin Reshapes Brain Networks for Weeks

          A new study reveals that psilocybin, the active compound in magic mushrooms, temporarily disrupts brain networks involved in introspective thinking, like daydreaming and memory. These changes persist for weeks, potentially making the brain more flexible and improving mental health. The findings could pave the way for psilocybin-based therapies for depression and PTSD. The research underscores the importance of using these drugs under medical supervision.
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          Reducing Visceral Fat Protects the Brain for Decades

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          Brain-First Hypothesis: Rethinking the Cambrian Explosion

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          Beyond the Gym: Why Your Brain Craves Creatine

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          Brain Switch for Action and Stress Identified

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