Psychostimulants increase dopamine levels, enhancing task-relevant cortical signals by acting on the striatum and the difference in dopamine synthesis capacity in the striatum explains the variability in the drugs' cognitive effects.
Patients with major depressive disorder who experienced trauma during childhood see symptom improvement following psychopharmacological intervention, psychotherapy, or a combination of both.
Automated computer-based training that focuses on positive words and images helps prolong the antidepressant effects of ketamine for those with treatment-resistant depression.
Spironolactone, a medication commonly used to lower blood pressure and for treating heart-related problems, shows potential for the treatment of alcohol use disorder.
Loperamide, a common anti-diarrhea medication, could help treat core symptoms associated with autism spectrum disorder. The drug activates the μ-opioid receptor, helping to improve social behaviors.
Prescribing psychedelic therapies including MDMA and psilocybin in combination with counseling and psychotherapy improve symptoms for those with PTSD.
A new study reports two doses of the psychedelic compound psilocybin reduced heavy alcohol consumption by 83% when combined with therapy for those with alcohol use disorder.
Both those who experienced a natural near-death experience and those who had a near-death experience while taking psychedelics report less fear of death and a lasting, spiritual positive experience.
Cannabidiol treatment helped reduce anxiety severity by, on average, 42.6% in young adults with treatment-resistant anxiety, a new study reports.
Researchers discuss how psychedelics can affect the brain and provide therapeutic benefits for those suffering from a range of psychiatric disorders.