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          psychopharmacology

          This shows a brain.
          FeaturedNeurosciencePsychology
          ·November 14, 2024·6 min read

          Brain Circuits Behind Psychedelics’ Anti-Anxiety Power Decoded

          New research has identified distinct neural circuits for the anti-anxiety and hallucinogenic effects of psychedelics. Using the psychedelic DOI in mice, researchers demonstrated that anxiety reduction persists long after hallucinatory effects subside.
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          This shows the molecular structure for ketamine.
          FeaturedNeurosciencePsychology
          ·November 14, 2024·7 min read

          “Lifesaving” Low-Dose Ketamine Unlocks Rapid Relief for Depression

          Researchers have identified how low-dose ketamine alleviates depression by selectively targeting specific NMDA receptors in the brain. Unlike high-dose anesthetic effects, low-dose ketamine binds to lateral grooves on NMDA receptors, enhancing excitatory transmission and long-term synaptic changes.
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          This shows an outline of a person sitting in a chair surrounded by swirly lines.
          FeaturedNeurosciencePsychology
          ·November 13, 2024·6 min read

          Schizophrenia Risks Tied to Psychedelic Use

          A new study links hallucinogen-related emergency department visits to a 21-fold increased risk of schizophrenia compared to the general population. Even after accounting for other mental health disorders and substance use, individuals faced a 3.5-fold higher risk.
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          This shows a psychedelic brain.
          FeaturedNeurosciencePsychology
          ·November 13, 2024·4 min read

          Psychedelic Therapy Could Benefit 5.6 Million People with Depression

          Psilocybin-assisted therapy could potentially benefit up to 5.6 million Americans with major depressive disorder or treatment-resistant depression, offering a powerful alternative to traditional treatments. Researchers applied medical criteria to a national pool of patients and found that over half might be eligible for psilocybin therapy, pending FDA approval. If approved, this therapy could significantly impact public health policies, insurance frameworks, and economic costs by reducing reliance on long-term antidepressant prescriptions.
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          This shows a woman and psychedelic swirls.
          FeaturedNeurosciencePsychology
          ·October 3, 2024·4 min read

          Psychedelics Reduce Anxiety Without Hallucinations

          New research has pinpointed the specific brain region and neuron type responsible for reducing anxiety using the psychedelic drug DOI, without triggering hallucinations. The study revealed that DOI targets serotonin2A receptors on parvalbumin-positive neurons in the ventral hippocampus, decreasing anxiety behaviors in animal models.
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          This shows a psychedelic brain.
          FeaturedNeurosciencePsychology
          ·September 24, 2024·3 min read

          Psychedelic Drug Reduces Anxiety by Targeting Fast-spiking Interneurons

          The psychedelic DOI, a compound similar to LSD, reduced anxiety in mice by activating specific brain cells called fast-spiking interneurons. These neurons silence nearby cells in the ventral hippocampus, a region linked to emotion and memory. By uncovering this mechanism, the study opens the door to designing new treatments that target anxiety without triggering hallucinations, a hallmark of many psychedelics.
          Read More
          This shows a brain.
          FeaturedNeurosciencePsychology
          ·September 24, 2024·4 min read

          Anti-inflammatory Drug Boosts Motivation in Depression

          A new study reveals that infliximab, an anti-inflammatory drug, can improve motivation in patients with depression and high inflammation. Researchers found that patients receiving infliximab showed greater effort in reward-based tasks, correlating with changes in brain activity in key motivation regions.
          Read More
          This shows a woman looking in a mirror.
          FeaturedNeurosciencePsychology
          ·September 24, 2024·2 min read

          Psilocybin Shows Promise in Treating Body Dysmorphic Disorder

          A new study reveals that psilocybin, the active compound in magic mushrooms, may help treat body dysmorphic disorder (BDD) by altering brain connectivity. In a pilot trial, patients with BDD showed significant improvements in symptoms after a single dose of psilocybin, with brain scans indicating increased neural flexibility. Though preliminary, the study suggests that psilocybin could offer new hope for BDD sufferers. Larger studies are needed to confirm its efficacy.
          Read More
          This shows a head and psychedelic swirls.
          FeaturedNeurosciencePsychology
          ·September 22, 2024·7 min read

          Psilocybin Shows Greater Long-Term Benefits Over SSRI for Depression

          A study comparing psilocybin to the SSRI escitalopram found both drugs improved depressive symptoms similarly over six months, but psilocybin offered additional psychosocial benefits. Patients taking psilocybin reported a greater sense of meaning, psychological connectedness, and improved social functioning. These results suggest psilocybin could provide a more holistic treatment option for depression, addressing both symptoms and overall well-being. While promising, psilocybin remains experimental and is only administered in controlled environments.
          Read More
          This shows pills and a head.
          FeaturedNeurosciencePsychology
          ·September 12, 2024·4 min read

          High Doses of ADHD Meds Linked to Increased Psychosis Risk

          Adults taking high doses of amphetamine-based medications for ADHD, such as Adderall, face a five-fold increased risk of developing psychosis or mania. The risk was highest for those taking 30 mg or more of dextroamphetamine, with 81% of psychosis or mania cases potentially avoidable by lowering the dose.
          Read More
          This shows a depressed woman.
          FeaturedNeurosciencePsychology
          ·August 23, 2024·5 min read

          Knowingly Taking Placebos Reduces Stress and Anxiety

          Researchers have discovered that nondeceptive placebos—placebos given with the full knowledge that they are placebos—can effectively manage stress, even when administered remotely. In a two-week randomized controlled trial, participants experiencing prolonged stress were divided into two groups: one group received nondeceptive placebos, while the other served as a control.
          Read More
          This shows a woman.
          FeaturedNeurosciencePsychology
          ·August 21, 2024·3 min read

          High-Dose Psilocybin Shows Potential as an Antidepressant Treatment

          A meta-analysis suggests that high doses of psilocybin may alleviate depressive symptoms similarly to the SSRI drug escitalopram. While the effect size was small, psilocybin outperformed placebo in clinical trials, though study design flaws could have led to overestimated results. The findings indicate that psilocybin, particularly in high doses, may offer a new avenue for treating depression, comparable to existing antidepressants.
          Read More
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          This shows two crying babies.

          Why Your Baby Cries: It’s Largely Written in Their Genes

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          Side of Parkinson’s Onset Shapes Cognitive and Emotional Decline

          This shows two brains.

          Timing of Prozac Treatment Shapes Lasting Mood, Brain Changes

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          Emotional Neglect in Childhood Undermines Trust in One’s Own Body

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