APOE4 increases the inflammatory response of human microglia while reducing cellular migration. The gene also impairs the metabolic activity of the immune cells. The findings show APOE4 has a profound impact on the basic functions of microglia.
Using zebrafish models, researchers detected genes with altered levels of expression. The genetic variations were associated with abnormalities with mitochondrial function and the production of ATP.
Elevated levels of LDL cholesterol has been linked to an increased risk of early-onset Alzheimer's disease, in those with and without a genetic risk factor. This suggests cholesterol could be an independent risk factor for dementia. Additionally, researchers identified a potential new genetic risk factor for early-onset Alzheimer's, a rare variant of the APOB gene.
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Researchers provide evidence that certain species of human herpesvirus contribute to the development of Alzheimer's disease. The study reports high levels of human herpesvirus 6A and 7 were found in brain samples showing signs of Alzheimer's neuropathology. The findings offer hints of the viral mechanisms that could trigger or exacerbate AD.
Researchers investigate the role the BMI1 gene plays in the onset and development of Alzheimer's disease. The study reports the loss of BMI1 triggers and increased production of amyloid beta and decreases neural ability to eliminate the protein.
Researchers have discovered a direct association between astrocytes and Alzheimer's disease. In a new study, researchers report astrocytes in the brains of Alzheimer's patients produced significantly more amyloid beta than astrocytes in the brains of people without the disease.
Researchers have identified biochemical changes that occur in the blood of people with an inherited form of Alzheimer's disease.
The same gene mutations linked to inherited, early-onset Alzheimer’s disease have been found in people with the more common late-onset...