DIPG cancer cells exposed to MI-2 fail to maintain healthy levels of cholesterol and die quickly, by inhibiting lanosterol synthase. Additionally, while MI-2 destroys glioma cancer cells, the drug does not damage healthy brain cells.
Based on a large scale meta analysis, researchers report striking differences between children's high grade gliomas, so much so that they could be split into 10 different subtypes based on different characteristics. The findings have important implications for developing new and individualized treatments.
Researchers have identified a specific rearrangement involving the NF2 gene that appears to cause radiation induced meningiomas. The Nature Communication study reports this mutation could be a basis for why many long term pediatric cancer survivors go on to develop brain tumors later in life.
Researchers report children born from mothers who underwent fertility treatment are at higher risk of developing neoplasms and pediatric cancers.
