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NLRP3

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Featured Neurology Neuroscience Open Neuroscience Articles

·March 3, 2020·6 min read

Visceral fat delivers signal to the brain that hurts cognition

Visceral fat impairs memory via proinflammatory interleukin-1 beta mediated microglia activation in the hippocampus.

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Featured Genetics Neurology Neuroscience

·February 24, 2020·4 min read

‘Resetting’ immune cells improves traumatic brain injury recovery

By inhibiting a particular receptor microglia use to survive, researchers reduced neuroinflammation and prompted recovery following traumatic brain injury in mouse models.

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Featured Neurology Neuroscience

·November 20, 2019·4 min read

Inflammatory processes drive progression of Alzheimer’s and other brain diseases

The NLPR3 inflammasome and the inflammatory response it triggers play a critical role in the emergence of tau pathology.

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Featured Genetics Neuroscience

·May 7, 2019·3 min read

Scientists pinpoint potential new target for regulating inflammation

SARM, an ancient immune protein previously implicated in apoptosis, is a key immune regulator in peripheral immune cells. The finding could help in the development of treatments for a range of diseases, including Alzheimer's, cancer and diabetes.

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Featured Neurology Open Neuroscience Articles

·December 20, 2017·4 min read

Inflammation Drives Progression of Alzheimer’s

Researchers report an inflammatory mechanism within the brain's immune system may drive the progression of Alzheimer's disease.

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Featured Genetics Neuroscience

·September 27, 2017·4 min read

Battling Belly Fat: Specialized Immune Cells Impair Metabolism in Aging

Researchers reveal how the macrophages become inflamed as we age and prevent neurotransmitters from functioning correctly.

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Featured Genetics Neurology

·April 27, 2017·5 min read

A Molecular Trigger For Brain Inflammation

Findings could help guide researchers to develop new drugs to treat Multiple Sclerosis and other neurological diseases.

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Featured Genetics

·February 2, 2017·5 min read

Universal Immune Mechanism as a Regulator of Sleep

Sleep may be regulated by inflammasome NLRP3, researchers report.

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Featured Neurology

·November 7, 2016·5 min read

Mapping the Biology of Drug Resistant Multiple Sclerosis

A new study may pinpoint an alternative treatment for people with drug resistant multiple sclerosis.

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Featured Neurology Open Neuroscience Articles

·August 11, 2016·4 min read

Anti-Inflammatory Drug Could Help Treat Alzheimer’s

A new study reports a commonly used NSAID anti-inflammatory drug was able to reverse memory loss in mouse models of Alzheimer's disease.