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neuropharmacology

Brain Cancer Featured Neurology Neuroscience

·May 13, 2025·7 min read

CAR-T Brain Fog Mirrors Chemo and COVID

Patients receiving CAR-T cell therapy often report brain fog, and new research shows this cognitive impairment stems from the therapy itself, not just the cancer or other treatments. A mouse study revealed that CAR-T-induced immune responses activate brain microglia, triggering inflammation that damages myelin-producing cells, reducing signal efficiency in the brain.

Featured Neurology Neuroscience

·May 12, 2025·6 min read

Brain Wave Phase Locking May Be Key to Unconsciousness

Despite acting through different molecular mechanisms, ketamine and dexmedetomidine both disrupt brain wave phase alignment in ways that reliably induce unconsciousness. A new study reveals that these anesthetics trigger a common signature: increased phase locking at low frequencies, particularly between brain hemispheres, while disrupting local cortical communication.

Featured Neurology Neuroscience

·May 8, 2025·4 min read

HIV Drugs Linked to Lower Alzheimer’s Risk

New research shows that HIV drugs called NRTIs may significantly reduce the risk of developing Alzheimer’s disease. Analyzing two large health databases, scientists found that patients on NRTIs had a 6% to 13% annual decrease in Alzheimer’s risk.

Featured Neuroscience

·May 7, 2025·7 min read

Western Diet Blocks Gut Microbiome Recovery After Antibiotics

New research shows that a Western-style diet rich in processed foods disrupts the gut microbiome’s ability to recover after antibiotic treatment. In mice, this diet prevented the regrowth of a healthy, diverse microbiome, leaving them more vulnerable to infections like Salmonella.

This shows a person sitting and mushrooms.

Featured Neurology Neuroscience

·April 30, 2025·6 min read

Psilocybin Shows Promise for Parkinson’s Mood and Motor Symptoms

A new pilot study reveals that psilocybin—the compound found in psychedelic mushrooms—may significantly improve mood, cognition, and motor function in people with Parkinson’s disease. The compound was well tolerated, with only mild side effects, and benefits persisted for weeks after dosing. While the study was primarily designed to test safety, researchers observed meaningful and lasting improvements in multiple symptoms.

Featured Neuroscience

·April 26, 2025·4 min read

Early Antibiotic Use Linked to Higher Childhood Obesity Risk

A new study reveals that taking antibiotics within the first two years of life is associated with higher childhood body mass index (BMI) and increased obesity risk. Researchers found that early antibiotic exposure raised BMI, and increased the risk of being overweight by 9% and obese by 20%.

Featured Genetics Neurology Neuroscience Pain

·April 23, 2025·4 min read

Clearing Zombie Cells Eases Back Pain

A new preclinical study has found that two drugs—o-Vanillin and RG-7112—can clear “zombie cells” from spinal discs, potentially treating the root cause of chronic low back pain. These senescent cells accumulate with age or injury and cause inflammation, pain, and tissue damage.

Featured Neuroscience

·April 22, 2025·7 min read

Reading Brainwaves to Fine-Tune Consciousness in Surgeries

A new clinical trial shows that using EEG to guide anesthesia in children significantly reduces the amount of anesthetic needed while improving post-surgery recovery. By monitoring brain wave patterns, anesthesiologists maintained safe unconsciousness with lower doses of sevoflurane, leading to faster awakening and fewer cases of post-anesthesia delirium.

Featured Neuroscience Psychology

·April 18, 2025·5 min read

Potential Depression Risk Linked to Ozempic-Like Drugs

A new international study reveals a possible connection between GLP1 receptor agonists—used in drugs like Ozempic—and increased risk of depression and suicidal ideation, especially in people with low dopamine function. Researchers used advanced pharmacogenomic tools to identify genetic pathways that may be vulnerable to dopamine dysregulation when exposed to these medications.

Featured Neurology Neuroscience

·April 16, 2025·5 min read

Ozempic Linked to Lower Alzheimer’s Risk

A new study suggests that two widely used Type 2 diabetes medications—GLP-1 receptor agonists and SGLT2 inhibitors—may help reduce the risk of Alzheimer’s disease and related dementias. Researchers analyzed Medicare data and found that patients taking these drugs had significantly lower rates of cognitive decline compared to those using other glucose-lowering medications.

Brain Cancer Featured Neurology Neuroscience

·April 9, 2025·3 min read

Chemotherapy Disrupts Brain Connectivity

New research reveals that chemotherapy can lead to rapid and widespread changes in brain connectivity in breast cancer patients. Using functional MRI scans, scientists observed disruptions in the frontal-limbic system and cerebellar cortex, regions involved in executive function and memory.

Featured Neurology Neuroscience Pain

·March 14, 2025·6 min read

Cannabis Terpenes Offer New Hope for Chronic Pain, Fibromyalgia

New research has identified cannabis-derived terpenes—compounds that give plants their distinctive aroma—as effective treatments for fibromyalgia and post-surgical pain. In preclinical mouse models, terpenes such as geraniol and linalool significantly reduced chronic pain, providing promising alternatives to opioid medications and avoiding THC's psychoactive side effects.

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neuropharmacology

CAR-T Brain Fog Mirrors Chemo and COVID

Brain Wave Phase Locking May Be Key to Unconsciousness

HIV Drugs Linked to Lower Alzheimer’s Risk

Western Diet Blocks Gut Microbiome Recovery After Antibiotics

Psilocybin Shows Promise for Parkinson’s Mood and Motor Symptoms

Early Antibiotic Use Linked to Higher Childhood Obesity Risk

Clearing Zombie Cells Eases Back Pain

Reading Brainwaves to Fine-Tune Consciousness in Surgeries

Potential Depression Risk Linked to Ozempic-Like Drugs

Ozempic Linked to Lower Alzheimer’s Risk

Chemotherapy Disrupts Brain Connectivity

Cannabis Terpenes Offer New Hope for Chronic Pain, Fibromyalgia

Brain Prioritizes “Sound Offsets” During Hearing Repair

Glucose Levels Signal the Growth of Myelin

Why Your Brain “Dreams” Even When You’re Awake

Mapping the Brain’s Hidden Hub for Creative Thought

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