FeaturedNeuroscience·February 18, 2023·2 min readHow AI Can Help Design Drugs to Treat Opioid AddictionResearchers are turning to artificial intelligence to find novel drugs that can block kappa opioid receptors with the hope to alleviate opioid addiction.Read More
FeaturedNeurosciencePsychology·February 16, 2023·3 min readReceptor Location Matters for Psychedelic Drug EffectsLocation bias may explain how psychedelic medications work. Researchers found that engaging serotonin 2A receptors inside neurons promotes the growth of new connections, but engaging the same receptor on the outside of a neuron does not. The findings may guide the development of new psychoplastogens to treat a range of disorders including depression and PTSD.Read More
FeaturedNeurologyNeuroscience·February 15, 2023·3 min readDrug Linked to Lower Risk of Dementia in People With DiabetesPeople with type 2 diabetes who took the drug pioglitazone were less likely to develop dementia later in life.Read More
AutismFeaturedNeuroscienceOpen Neuroscience Articles·February 14, 2023·4 min readDrug Shown to Alleviate Autism-Associated BehaviorA newly developed drug that blocks sodium channels in the cell membrane that can reverse MYT1L failure alleviates social behavior deficits in mouse models of ASD.Read More
FeaturedNeurologyNeuroscience·February 13, 2023·5 min readStudy Reveals How CBD Counters Epileptic SeizuresCannabidiol, or CBD, blocks the ability of lysophosphatidylinositol (LPI) to amplify neural signals in the hippocampus. LPI weakens the signals that counter seizures, further explaining the value of CBD to treat epilepsy.Read More
FeaturedNeurologyNeuroscience·February 6, 2023·5 min readPromising Treatment for Alzheimer’s DiseaseUsing theranostics to pinpoint and treat the earliest, preclinical symptoms of Alzheimer's disease, researchers say their new method shows promise in stopping the progression of Alzheimer's pathologies before the onset of irreversible neural damage.Read More
FeaturedNeurologyNeuroscienceOpen Neuroscience ArticlesPain·February 2, 2023·7 min readAntidepressants Use for Chronic Pain on the Rise, but Are They Effective?SNRI antidepressants appear to be effective in the treatment of a range of pain conditions including neuropathic pain, fibromyalgia, and postoperative pain. Tricyclic antidepressants may not be effective in the treatment of pain.Read More
FeaturedNeurologyNeuroscience·January 31, 2023·4 min readDo Sleep Medications Increase Your Chances of Dementia?People who frequently take sleeping medications are 79% more likely to develop dementia than those who never use sleeping pills to aid their rest.Read More
FeaturedNeurosciencePainPsychology·January 30, 2023·5 min readHow Ketamine Acts as Antidepressant in Chronic PainChronic pain in mice activates Tiam1 in pyramidal neurons in the anterior cingulate cortex, increasing the number of dendritic spines and inducing synaptic plasticity. Ketamine's antidepressant effect in chronic pain is mediated by the drug blocking Tiam1-dependent maladaptive synaptic plasticity in ACC neurons.Read More
FeaturedNeurologyNeuroscience·January 29, 2023·4 min readIn Search of the Optimal Migraine ReliefUsing oral transmucosal delivery of eletriptan hydrobromide delivers faster and more effective relief for migraine sufferers.Read More
FeaturedGeneticsNeurologyNeuroscienceOpen Neuroscience Articles·January 25, 2023·4 min readDrug That Targets Tauopathies in Mice Reveals Sex Differences in ResponseExposure to drugs that target tauopathies extended survival, reduced neurodegenerative biomarkers, and functionally reduced aberrant behaviors in female mice, but not in males.Read More
FeaturedNeurologyNeuroscience·January 24, 2023·4 min readHow a Brain Molecule Could Halt Multiple SclerosisInjecting the brain molecule into mouse models of multiple sclerosis increased the number of oligodendrocytes. The findings suggest fractalkine may help to slow the progression, or potentially halt multiple sclerosis.Read More