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neuropharmacology

·July 13, 2025·5 min read

Weekly Injection Could Revolutionize Parkinson’s Treatment

Researchers have developed a long-acting weekly injection that delivers steady doses of levodopa and carbidopa, potentially transforming care for Parkinson’s disease. The biodegradable injectable maintains consistent drug levels, reducing the need for multiple daily pills and improving patient adherence.

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·July 11, 2025·5 min read

Common Pain Medication Linked to Cognitive Decline Risk

A large U.S. medical records study has found that adults prescribed gabapentin six or more times for chronic low back pain face significantly higher risks of dementia (29%) and mild cognitive impairment (85%) within 10 years. The risks were especially pronounced in younger adults aged 35–64, where rates of cognitive decline more than doubled or tripled compared to those not on the drug.

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·July 1, 2025·5 min read

Cough Medicine Shows Promise in Slowing Parkinson’s Dementia

A clinical trial has revealed that Ambroxol, a common cough medicine in Europe, may help slow cognitive decline in people with Parkinson’s disease dementia. The 12-month study found that the drug stabilized psychiatric symptoms, protected against brain damage, and even improved cognition in genetically at-risk participants.

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·June 30, 2025·6 min read

Mimicking Exercise in the Brain Could Slow Cognitive Decline

While physical activity is known to slow cognitive decline in Alzheimer’s disease, many patients are unable to exercise due to frailty or advanced symptoms. A new study identifies a specific gene, ATPPIF1, that is reactivated through exercise and supports neuroplasticity in the brain.

This shows a person holding their head in pain.

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·June 24, 2025·3 min read

GLP-1 Drug Cuts Migraine Days in Half

A new study finds that the diabetes drug liraglutide significantly reduced monthly migraine days in patients with obesity and chronic migraine. Participants reported an average of 11 fewer headache days per month, alongside improved disability scores and quality of life.

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·June 18, 2025·5 min read

RyR1 Channel Triggers Sedation from Anesthetics

A new study uncovers the long-elusive mechanism of inhalational anesthetics by identifying the RyR1 calcium channel as a key molecular target. Researchers demonstrated that anesthetics like isoflurane activate RyR1 to trigger calcium release from the endoplasmic reticulum, a crucial step in inducing general anesthesia.

Featured Neurology Neuroscience Pain

·June 10, 2025·3 min read

How Acetaminophen Silences Pain Before It Reaches the Brain

Paracetamol (acetaminophen) doesn’t just work in the brain—it also shuts off pain at its source in the peripheral nerves. The study found that after taking paracetamol, the body produces a compound called AM404 directly in pain-sensing nerve endings.

Featured Genetics Neurology Neuroscience

·June 5, 2025·7 min read

HIV Drugs Linked to Lower Alzheimer’s Risk

FDA-approved HIV drugs targeting reverse transcriptase (RT) may reduce Alzheimer’s risk by blocking similar enzymatic activity in the aging brain. Scientists discovered unexpected RT activity in neurons of healthy and Alzheimer’s brains, tracing it to truncated LINE1 elements—ancient genetic sequences capable of copying themselves via RT.

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·June 3, 2025·7 min read

Ibudilast Fails to Beat Placebo in Alcoholism Trial, Except in Women

A recent clinical trial found that ibudilast, a drug once promising for alcohol use disorder, was no more effective than a placebo overall. While all participants reduced their drinking, women on ibudilast showed a greater drop in drinks per day, hinting at a gender-specific benefit.

This shows an older woman with a tincture.

Featured Neuroscience

·June 3, 2025·5 min read

Cannabis Use Among U.S. Seniors Has Surged 46% in Just Two Years

Marijuana use among U.S. adults aged 65 and older has climbed to a record 7%, up nearly 46% from 2021 to 2023. The trend is especially pronounced among college-educated, married, and higher-income individuals, particularly women.

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·May 31, 2025·8 min read

Blocking Opioid Receptors May Restore Healthy Dopamine Balance

New research identifies a promising strategy for correcting dopamine imbalances in the brain using a drug that blocks kappa opioid receptors (KOR). In mouse models with a rare mutation that causes dopamine to leak abnormally, KOR blockers reduced this leakage and restored normal behavior.

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·May 30, 2025·4 min read

SSRIs Restore Brain Function in Alzheimer’s

A new study suggests that SSRIs, commonly prescribed antidepressants, may reduce biological markers of Alzheimer’s disease. In a cohort of 191 individuals, AD patients on SSRIs had lower levels of plasma phosphorylated tau-181, a key indicator of disease severity.