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neuropharmacology

·March 8, 2023·6 min read

How the Brain Senses Infection

A small group of neurons in the airway plays a key role in altering the brain of the presence of flu infection in the body, and a second pathway from the lungs to the brain becomes active later in infection. The findings also shed light on how NSAID anti-inflammatory medications alleviate flu symptoms.

Brain Cancer Featured Neuroscience

·March 7, 2023·7 min read

Revolutionary Brain Tumor Breakthrough Unveils Promising New Drug Treatments

In recent research, scientists have discovered that blood vessels feeding high-grade glioma brain tumors have high levels of LDL receptors (LDLR) on them. The study found that using drug-containing nanoparticle-based therapies to target these receptors can be a new way of treating cancer. Gliomas are the most common primary brain tumors and, due to their highly aggressive nature, have a poor prognosis with an average survival of only 4.6 months without treatment and approximately 14 months with optimal multimodal treatments. This research could pave the way for treating glioma brain tumors with LDL receptor-targeted nanoparticle-based therapies, thereby cutting off the energy supply of cancer cells.

Featured Neurology Neuroscience Open Neuroscience Articles

·March 2, 2023·4 min read

AI Semantic Similarity Study Leads to Novel Drug Candidates for Parkinson’s Disease

Using AI, researchers identified Probucol, an existing anti-cholesterol drug that promotes the disposal of mitochondria, as a potential new therapy for the treatment of Parkinson's disease.

Featured Neurology Neuroscience

·March 1, 2023·3 min read

Degrading Modified Proteins Could Treat Alzheimer’s and Other “Undruggable” Diseases

Researchers have developed a compound that can target and break down a post-transitionally modified protein associated with Alzheimer's disease.

Brain Cancer Featured Neuroscience

·February 28, 2023·6 min read

Identifying the Inflammatory Cells Behind Chemo Brain

Microglia appear to be associated with brain fog and memory problems that arise as a result of exposure to chemotherapy, researchers discovered. Deleting the immune cells from the microglia in mice who received the chemotherapy drug paclitaxel lowered inflammation and restored memory function.

Featured Neurology Neuroscience

·February 27, 2023·3 min read

AI Tool May Speed Screening of Epilepsy Drugs in Mice

Artificial intelligence was able to determine different behavioral phenotypes at different stages in the development of epilepsy in mice.

Featured Neuroscience Psychology

·February 21, 2023·5 min read

Medication Targeting Brain Stress Response May Help Cardiovascular Symptoms of Alcohol Withdrawal

Prazosin, an FDA-approved medication for the treatment of hypertension may help to prevent relapse in people with cardiovascular and behavioral symptoms of alcohol withdrawal, a new study reports.

Featured Neuroscience Open Neuroscience Articles

·February 21, 2023·4 min read

Brain Circuit Involved in Fentanyl Abuse and Relapse Identified

Fentanyl enhances direct pathway medium spiny neurons activity in the striatum. During withdrawal from the opioid, inhibitory signals from direct pathway medium spiny neurons to dopaminergic neurons become enhanced. The enhanced suppression of dopaminergic neurons contributes to the negative emotions associated with fentanyl withdrawal. Inhibiting the direct pathway medium spiny neurons can reduce withdrawal symptoms and associated anxiety behaviors.

Featured Neuroscience

·February 18, 2023·2 min read

How AI Can Help Design Drugs to Treat Opioid Addiction

Researchers are turning to artificial intelligence to find novel drugs that can block kappa opioid receptors with the hope to alleviate opioid addiction.

Featured Neuroscience Psychology

·February 16, 2023·3 min read

Receptor Location Matters for Psychedelic Drug Effects

Location bias may explain how psychedelic medications work. Researchers found that engaging serotonin 2A receptors inside neurons promotes the growth of new connections, but engaging the same receptor on the outside of a neuron does not. The findings may guide the development of new psychoplastogens to treat a range of disorders including depression and PTSD.

Featured Neurology Neuroscience

·February 15, 2023·3 min read

Drug Linked to Lower Risk of Dementia in People With Diabetes

People with type 2 diabetes who took the drug pioglitazone were less likely to develop dementia later in life.

Autism Featured Neuroscience Open Neuroscience Articles

·February 14, 2023·4 min read

Drug Shown to Alleviate Autism-Associated Behavior

A newly developed drug that blocks sodium channels in the cell membrane that can reverse MYT1L failure alleviates social behavior deficits in mouse models of ASD.