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neuropharmacology

·February 13, 2023·5 min read

Study Reveals How CBD Counters Epileptic Seizures

Cannabidiol, or CBD, blocks the ability of lysophosphatidylinositol (LPI) to amplify neural signals in the hippocampus. LPI weakens the signals that counter seizures, further explaining the value of CBD to treat epilepsy.

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·February 6, 2023·5 min read

Promising Treatment for Alzheimer’s Disease

Using theranostics to pinpoint and treat the earliest, preclinical symptoms of Alzheimer's disease, researchers say their new method shows promise in stopping the progression of Alzheimer's pathologies before the onset of irreversible neural damage.

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·February 2, 2023·7 min read

Antidepressants Use for Chronic Pain on the Rise, but Are They Effective?

SNRI antidepressants appear to be effective in the treatment of a range of pain conditions including neuropathic pain, fibromyalgia, and postoperative pain. Tricyclic antidepressants may not be effective in the treatment of pain.

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·January 31, 2023·4 min read

Do Sleep Medications Increase Your Chances of Dementia?

People who frequently take sleeping medications are 79% more likely to develop dementia than those who never use sleeping pills to aid their rest.

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Featured Neuroscience Pain Psychology

·January 30, 2023·5 min read

How Ketamine Acts as Antidepressant in Chronic Pain

Chronic pain in mice activates Tiam1 in pyramidal neurons in the anterior cingulate cortex, increasing the number of dendritic spines and inducing synaptic plasticity. Ketamine's antidepressant effect in chronic pain is mediated by the drug blocking Tiam1-dependent maladaptive synaptic plasticity in ACC neurons.

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·January 29, 2023·4 min read

In Search of the Optimal Migraine Relief

Using oral transmucosal delivery of eletriptan hydrobromide delivers faster and more effective relief for migraine sufferers.

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·January 25, 2023·4 min read

Drug That Targets Tauopathies in Mice Reveals Sex Differences in Response

Exposure to drugs that target tauopathies extended survival, reduced neurodegenerative biomarkers, and functionally reduced aberrant behaviors in female mice, but not in males.

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·January 24, 2023·4 min read

How a Brain Molecule Could Halt Multiple Sclerosis

Injecting the brain molecule into mouse models of multiple sclerosis increased the number of oligodendrocytes. The findings suggest fractalkine may help to slow the progression, or potentially halt multiple sclerosis.

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·January 23, 2023·3 min read

Hypertension Drug Could Be Repurposed to Delay Aging

Rilmenidine, a drug commonly prescribed to help treat hypertension can help slow the effects of aging and extend lifespan, a new study reports.

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·January 21, 2023·4 min read

Researchers Synthesize Ocean-Based Molecule That Could Fight Parkinson’s

Researchers have successfully created a synthetic version of a small molecule found in a recently discovered sea sponge that appears to have therapeutic benefits for Parkinson's disease.

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·January 15, 2023·5 min read

Old Antipsychotic Drugs May Offer New Option to Treat Type 2 Diabetes

Diphenylbutylpiperidines (DPBPs), an older class of antipsychotic medications can effectively be repurposed to help treat type 2 diabetes, a new study reports.

Featured Neuroscience Pain

·January 13, 2023·6 min read

Scientists Take Another Step Toward Building a Better, Safer Opioid

Using cryoEM technology, researchers have decoded the detailed structures of an entire family of opioid receptors bound to their naturally occurring peptides. This new structural framework should help in the development of safer, more effective medications to treat chronic pain.