Mouse study reveals synaptic loss associated with a daily sleep-inducing dose of diazepam for several weeks leads to cognitive impairments. However, the effect was reversible after discontinuing benzodiazepine use.
Cyclodextrin, an FDA-approved drug, reduced cholesterol accumulation from broken down brain cells and inflammation in animal models. The findings point to a potential new therapy to reduce dementia following a stroke.
PsychLight, a newly developed genetically encoded fluorescent sensor, helped researchers identify a psychedelic compound that acts on beneficial neural pathways to treat psychiatric disorders without the hallucinogenic effect.
Rotigotine, a drug that acts on dopamine transmission, improves cognitive function in patients with mild-to-moderate Alzheimer's disease. While the drug did not help improve memory, it did improve executive function in the frontal lobe and positively impacted the ability of patients to perform activities of daily living.
Dantrolene, a common muscle relaxant, shows promise in the treatment of Alzheimer's disease. Mice administered the drug intranasally had higher concentrations of the medicine in their brains, and for longer periods, than those who received it orally. The drug has been shown to help inhibit or slow the progression of several neurodegenerative diseases.