Salt crystals can precipitate at low concentrations due to local density fluctuations. Their repeated precipitation dissolution behavior promotes amyloid-beta peptide aggregation. Read More
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Being vaccinated against influenza was associated with a 17% reduction in Alzheimer's incidence. Pneumonia vaccinations given between the ages of 65 and 75, reduced Alzheimer's risk by up to 40%. Read More
Spinal cord injuries cause stem cells in the bone marrow to rapidly divide. Following the cell division, the stem cells become trapped in the bone marrow. Read More
Genomic research finds those who inherited a special ion channel from Neanderthals experience more pain. Read More
In both human cell and mouse models of Huntington's disease, RNA from mitochondria was misplaced within spiny projection neurons. The stray RNAs, which looked different to cells than RNA derived from the cell nucleus, trigger an immune reaction that can lead to striatal cell type vulnerability. Read More
Older adults with a higher ability to process sensations, including vision, olfaction, hearing, and touch, had half the risk of being diagnosed with cognitive decline than their peers who were less capable at sensory processing tasks. Read More
Analysis of over 2,000 brain scans revealed evidence of highly reproducible sex differences in the volume of different regions of the brain. On average, females had greater cortical volume in the medial and lateral prefrontal cortex, orbitofrontal cortex, superior temporal cortex, and lateral parietal cortex. Males had increased volume in the ventral temporal and occipital brain regions. Gene expression data suggest the potential role of sex chromosomes that contribute to the differences. Read More
Oxytocin, the so-called "love hormone," could help to treat cognitive disorders, including Alzheimer's disease. Researchers demonstrated oxytocin reversed the effects of amyloid-beta on hippocampal LTP in mice. The findings suggest oxytocin could be used as a therapeutic for the treatment of Alzheimer's disease and other dementias. Read More
APOEe4, a gene associated with Alzheimer's disease risk, doesn't appear to directly affect memory performance or brain activity in older adults without cognitive impairment. However, the gene does seem to influence brain regions and systems that older at-risk adults activate to support successful memory recall. Read More
A mutated form of the huntingtin protein disrupts the normal movement of vesicles holding HT and Rab4. This leads to defects in synapses, resulting in movement abnormalities and lifespan decreases in fruit fly larvae. Findings suggest Rab4 could be a novel therapeutic target for the early intervention of Huntington's disease, before the neuronal loss and behavioral deficits associated with the neurodegenerative disorder. Read More
Mundane behaviors repeated over time, and occur in the context of other similar behaviors can lead to conflated intentions, which cause false memories of completing the task. Read More
Study identified a new class of proteins that protect synapses from being destroyed. The findings have important implications for both Alzheimer's disease and schizophrenia. Read More
