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Multiple Sclerosis

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·June 5, 2019·3 min read

Nanotechnology treatment reverses multiple sclerosis in mice

Extracting nanosized exosomes from bone marrow stem cells and injecting them into mice, researchers reverse symptoms of multiple sclerosis.

This shows the structure of the compound

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·May 29, 2019·4 min read

New compounds could be used to treat autoimmune disorders

Researchers have developed small molecules that inhibit one of the main enzymes implicated in autoimmune response. The research could lead to potential new medications for a range of autoimmune diseases.

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·May 29, 2019·4 min read

Red meat as part of a healthy diet linked to reduced risk of multiple sclerosis

Combining unprocessed red meat with the Mediterranean diet has been associated with a reduced risk of developing multiple sclerosis.

This shows a woman covering her face with her hands

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·May 26, 2019·6 min read

Autoimmune disease and stress: Is there a link?

Researchers consider why those with autoimmune diseases are more likely to have a previous diagnosis of stress-related disorders.

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·May 14, 2019·4 min read

How stressed-out gut bacteria may trigger autoimmune response

Chronic social stress in mice induces the expression of virulent genes in the gut microbiota. The altered microbiota increases the presence of effector T helper cells in the lymph nodes and induces myelin autoreactive cells. Exposure to chronic stress, therefore, may increase the risk of developing autoimmune diseases for some individuals with a susceptibility.

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·May 10, 2019·6 min read

Statins’ potential to treat MS unrelated to lowering cholesterol

The common statin drug Simvastatin reduces brain atrophy and slows the progression of secondary progressive multiple sclerosis (SPMS). The effects appear to be independent of the drug's cholesterol-lowering effects.

This diagram shows how ms affects the body

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·May 8, 2019·4 min read

A new culprit for multiple sclerosis relapses

Injecting extracellular vesicles from healthy mice into mice that had an MS-like disease resulted in the development of a relapse-remitting disease and active CD8+ cells, similar to that seen in human patients with multiple sclerosis. Examining the EVs in mice and humans with MS, researchers identified they contained fibrinogen, a protein normally associated with blood clotting and wound healing. According to researchers, the EVs with fibrinogen appear to activate the CD8+ immune cells. The findings could help with the development of new treatments for RRMS.

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·May 6, 2019·5 min read

Pigment-producing stem cells can regenerate myelin sheath: Mouse study

Skin-related stem cells may be key to helping restore the myelin sheath in patients with multiple sclerosis. Using mouse models, researchers discovered melanocyte stem cells can, under the right conditions, function as cells that create myelin.

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·April 27, 2019·2 min read

New research reviews the state of vaccine safety science

Researchers will present a systematic review of scientific evidence for, and against causal associations for 47 proposed adverse events following immunizations at PAS 2019. The review found that, for 12 of the 47 AEFIs in the study, a causal relationship has been established with at least one vaccine. With the exception of deltoid bursitis, where a vaccine is administered incorrectly, causing pain to the arm, the adverse reactions are very rare. For the other 35 AEFis, the evidence does not support a causal relationship between conditions, such as ASD, asthma, diabetes, multiple sclerosis or SIDs, and vaccinations.

This shows the myelin regrowth on neurons

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·April 25, 2019·3 min read

Stem cells from hair follicles have potential to repair myelin sheath in mice

Melanocyte stem cells from human hair follicles that carry CD34 have the ability to turn into glial cells. The CD34+ stem cells can regenerate myelin, both on neurons and in mouse models with a genetic defect that prevents the formation of healthy myelin sheaths. The findings could have positive implications for the treatment of demyelinating diseases, such as Multiple Sclerosis.

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·April 18, 2019·5 min read

Study shows promise in repairing damaged myelin

A study in mouse models of multiple sclerosis demonstrates a compound called sobetirome promotes remyelination, and a derivative of the compound can penetrate the blood-brain barrier to enable a tenfold increase in infiltration to the CNS. Researchers are confident their research will translate from mice into humans, providing a new avenue of treatment for MS.

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·April 17, 2019·3 min read

Vitamin D study sheds light on immune system effects

Vitamin D causes dendritic cells to produce more CD31, hindering the activation of T cells. The study sheds light on how vitamin D deficiency regulates the immune system and can lead to autoimmune diseases, like multiple sclerosis.