Multiple Sclerosis

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12 genes at the root of multiple sclerosis identified

12 genes associated with familial multiple sclerosis have been identified. The findings provide a molecular rationale for the chronic inflammation, demyelination and neurodegeneration associated with MS. Identifying new genetic targets could help with the development of novel treatments to prevent multiple sclerosis in those with a genetic risk.... Read More...
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How stressed-out gut bacteria may trigger autoimmune response

Chronic social stress in mice induces the expression of virulent genes in the gut microbiota. The altered microbiota increases the presence of effector T helper cells in the lymph nodes and induces myelin autoreactive cells. Exposure to chronic stress, therefore, may increase the risk of developing autoimmune diseases for some individuals with a susceptibility.... Read More...
This diagram shows how ms affects the body

A new culprit for multiple sclerosis relapses

Injecting extracellular vesicles from healthy mice into mice that had an MS-like disease resulted in the development of a relapse-remitting disease and active CD8+ cells, similar to that seen in human patients with multiple sclerosis. Examining the EVs in mice and humans with MS, researchers identified they contained fibrinogen, a protein normally associated with blood clotting and wound healing. According to researchers, the EVs with fibrinogen appear to activate the CD8+ immune cells. The findings could help with the development of new treatments for RRMS. ... Read More...
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New research reviews the state of vaccine safety science

Researchers will present a systematic review of scientific evidence for, and against causal associations for 47 proposed adverse events following immunizations at PAS 2019. The review found that, for 12 of the 47 AEFIs in the study, a causal relationship has been established with at least one vaccine. With the exception of deltoid bursitis, where a vaccine is administered incorrectly, causing pain to the arm, the adverse reactions are very rare. For the other 35 AEFis, the evidence does not support a causal relationship between conditions, such as ASD, asthma, diabetes, multiple sclerosis or SIDs, and vaccinations.... Read More...