Stem cell transplant reverses disabling MS-like disease
Hematopoietic stem cell transplantation reversed neuromyelitis optica. Five years following transplantation, only 2 of twelve patients had relapsed.... Read More...
Multiple Sclerosis
Surprise contributor to multiple sclerosis identified
Oligodendrocyte progenitor cells (OPCs) actively contribute to neuroinflammation associated with multiple sclerosis.... Read More...
Targeting certain rogue T cells prevents and reverses multiple sclerosis: Mouse study
TH17 cells produced increased amounts of SerpinB1, a protein implicated in multiple sclerosis symptoms. SerpinB1 cells were identified with antibodies targeting the CXCR6 surface protein. Using monoclonal antibodies to target CXCR6, the cells disappeared significantly, and the mice primed to develop MS did not develop the disease.... Read More...
Treating inflammation with inflammation
Ter119, an inflammatory antibody, has the potential to treat inflammation caused by autoimmune diseases, according to the findings of a new rodent study.... Read More...
X chromosome gene may explain why women are more prone to autoimmune diseases
Kdm6a, a gene on the X chromosome appears to be associated with the development of autoimmune diseases, such as Multiple Sclerosis. The gene is expressed more in the immune cells of females than males. When Kdm6a was deleted in mouse models of MS, the animals had improved symptoms and reduced inflammation. The findings shed light on why women are more prone to autoimmune diseases than males.... Read More...
Vegetable-rich Wahls diet lowers fatigue in multiple sclerosis patients by raising good cholesterol
Eating a diet high in vegetables can help reduce symptoms of fatigue in those with progressive multiple sclerosis. ... Read More...
Scientists reverse aging process in rat brain stem cells
Removing Piezo1 from the surface of aged brain stem cells caused the cells to become rejuvenated and regain their normal regenerative function.... Read More...
Smoldering spots in the brain may signal severe MS
Dark rimmed spots on the brain that represent ongoing inflammation, known as chronic active lesions, may be a hallmark of a more aggressive and debilitating form of multiple sclerosis. The findings provide a new biomarker for diagnosing the neurological disorder.... Read More...
Adding MS drug to targeted cancer therapy may improve glioblastoma outcomes
Teriflunomide, a drug commonly used to treat multiple sclerosis, shows promise for the treatment of glioblastoma when coupled with targeted cancer therapies.... Read More...
Vaccinations not a risk factor for multiple sclerosis
A study of over 200,000 people found no evidence that vaccinations increase the risk of developing multiple sclerosis, or the onset of an initial MS episode. ... Read More...
Fingerprint of Multiple Sclerosis Immune Cells Identified
T helper cells in the blood of patients with multiple sclerosis infiltrate the central nervous system, causing inflammation and neural damage. ... Read More...
Study pinpoints cell types affected in brains of multiple sclerosis patients
Projection neurons have been implicated in the progression of multiple sclerosis. A new study reports projection neurons are damaged by immune cells. This damage could contribute to both atrophy and cognitive changes associated with the disease.... Read More...