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microscopy

·May 24, 2025·3 min read

New Tool Tracks Individual Brain Cells in Mice for Up to 99 Days

Tracking the same neurons in the brain over time has long challenged neuroscientists using calcium imaging in freely moving mice. A new analytical tool called CaliAli overcomes these limitations by aligning imaging data across sessions with remarkable accuracy.

Featured Neuroscience

·May 8, 2025·7 min read

New Method Maps Brain Networks With Unprecedented Detail

A revolutionary microscopy method called LICONN enables scientists to reconstruct brain tissue and map synaptic connections using standard light microscopes. By embedding brain tissue in hydrogel, expanding it, and imaging at nanoscale resolution, researchers achieve a detailed view of neuronal architecture previously only possible with electron microscopy.

Featured Neuroscience

·June 4, 2024·6 min read

New Microscopy System Tracks Brain Changes Faster and Clearer

Researchers developed a new microscopy system, mosTF, to track brain plasticity more efficiently. This system scans tissue with lines of light in perpendicular directions, providing faster and clearer imaging than traditional two-photon microscopy. The mosTF system enhances our ability to study rapid neural changes, crucial for understanding brain function and disorders.

Featured Neuroscience

·May 9, 2024·6 min read

Microscopic Brain Tissue Map Reveals Vast Neural Networks

Researchers created the largest 3D reconstruction of human brain tissue at synaptic resolution, capturing detailed images of a cubic millimeter of human temporal cortex. This tiny piece of brain contains 57,000 cells, 230 millimeters of blood vessels, and 150 million synapses, which amounts to 1,400 terabytes of data.

Featured Neuroscience

·April 18, 2023·5 min read

Revealing the Entire Mouse Brain in Unprecedented Detail: Brain Images Just Got 64 Million Times Sharper

Researchers dramatically improved the resolution of MRI imaging technology, leading to the sharpest images ever generated of the mouse brain.

Featured Neuroscience

·March 21, 2023·4 min read

Wearable Microscopes Advance Spinal Cord Imaging in Mice

A newly invented wearable microscope produces high-definition and real-time images of neurons and activity in the mouse spinal cord in previously inaccessible regions.

Featured Neuroscience

·January 25, 2023·2 min read

Mini2P Microscope Goes Global

The Mini2P microscope can be used to record brain activity in live, freely moving mice.

Featured Neuroscience

·October 24, 2022·4 min read

How Psychedelics Light Up Brain’s Neuropathways

Study reveals the basic neurobiology of how psychedelics work at the chemical, molecular, neural, and network levels within the brain.

This shows the researchers holding up the microscope

Featured Neuroscience

·March 20, 2022·7 min read

An Open-Source Miniature Brain Microscope

A new miniature brain microscope, dubbed Mini2P, allows researchers to study neural network activity at high resolution in animals behaving naturally.

This shows synapses and neurons imaged with the new method

Featured Neuroscience

·January 13, 2022·6 min read

Next-Generation Tissue Expansion Method Improves Neural Imaging

Researchers have developed a new method that vastly improves the imaging of the structures of neural connections using standard confocal microscopes.

Featured Neuroscience

·September 15, 2021·5 min read

New Microscopy Technique Reveals Activity of One Million Neurons Across the Mouse Brain

A new technique dubbed light beads microscopy allowed researchers to generate a vivid functional movie of the near-simultaneous activity of almost a million neurons in the mouse brain.

Neuroscience

·August 30, 2021·5 min read

New Microscopy Technique Reveals Activity of One Million Neurons Across the Mouse Brain

A new microscopy technique allows researchers to capture detailed images of the activity of vast amounts of neurons across different depths in the brain at high speed and clarity.