Researchers identified 33 metabolic compounds in blood samples that differed between those with dementia and cognitively healthy older adults. 7 of the metabolites were elevated in dementia patients, while 26 were at lower levels compared to samples of those without dementia. Elevating levels of those metabolites could have a neuroprotective effect against dementia.
Lower serum levels of the sugar metabolite GlcNAc was associated with progressive disability and neurodegeneration in patients with multiple sclerosis.
Two to five years after birth, mothers of children on the autism spectrum have several significantly different metabolite levels than mothers of typically developing children.
Recent clinical trials show urolithin A, a compound derived from molecules in pomegranates, can slow the aging process. Urolithin A improves mitochondrial function following oral consumption.
Preterm babies who were fed breastmilk had significantly higher levels of creatine and choline, key metabolites for brain growth and development, than those who were formula fed.
Antidepressants, such as the SSRI amitriptyline, antibiotics associated with developmental problems and sun cream components are contaminating water, and are being accumulated in fish. Exposure to the medications has effects on the molecular level to the fish. Researchers say this poses a problem as consumption of gilt-head bream is on the rise, and there could be a risk of the contaminants reaching humans via diet.
Maternal obesity is associated with differences in breast milk composition from that of mothers with a lower BMI. The variations of the metabolites may contribute to a higher risk of childhood obesity in children whose mothers are overweight. The findings point to a potential breast milk dependent mechanism for the mother-child transmission of obesity.
Researchers report UroA, a microbial metabolite derived from a compound found in pomegranates and berries, can reduce and protect against inflammatory bowel disease.
A new study reveals a link between elevates microbiome levels of indole and hedonic eating. Researchers report those with higher levels of indole are more likely to have food addiction and overeating disorders.