Lupus

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Lupus

·August 21, 2022·4 min read

Lupus Pill Shows Promise in Mice; Clinical Trial Underway

Afimetoran, a newly developed pill to treat lupus, not only prevents lupus-like symptoms in mice, it also reverses signs of organ damage caused by the disease and prevents death. The medication is now undergoing phase 2 clinical trials to assess its effectiveness in lupus patients.

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·December 8, 2021·3 min read

Trigger Found for Harmful Inflammation in Lupus and Macular Degeneration

Age-related macular degeneration and lupus share a common contributor to inflammation. The findings could help researchers develop new treatments for those conditions, and other conditions associated with inflammation.

Featured Genetics Neurology

·February 11, 2021·5 min read

Spinal Fluid of People With Alzheimer’s Risk Gene Signals Inflammation

People with the APOE4 genetic risk factor for Alzheimer's disease also have lower levels of the CRP inflammatory molecules in their spinal fluid. Researchers speculate these inflammatory molecules may be accumulating in the brain and causing damage, rather than floating freely in cerebrospinal fluid.

Featured Neurology Neuroscience

·January 7, 2021·4 min read

Ginger Counters Certain Autoimmune Diseases in Mice

6-gingerol, the main bioactive compound of ginger root, appears to counteract mechanisms that fuel autoimmune disorders such as lupus and antiphospholipid syndrome in mice.

Featured Genetics Neuroscience Psychology

·May 11, 2020·9 min read

Researchers pinpoint genes behind sex biases in autoimmune disorders and schizophrenia

A new study reveals why women are more likely to develop autoimmune conditions like lupus and Sjögren's syndrome, and men are more likely to develop schizophrenia. Researchers implicated the C4 gene in sex-based risk factors for autoimmune and psychiatric disorders.

Featured Neurology Neuroscience Open Neuroscience Articles

·August 7, 2019·4 min read

Blood clotting proteins in urine discovered as biomarkers of lupus nephritis

Clotting proteins are elevated in the urine of patients with lupus nephritis. The findings provide a new biomarker for the autoimmune disease.

This diagram shows how lupus affects the body

Featured Genetics Neuroscience

·July 2, 2019·3 min read

B cells off the rails early in lupus

A key finding in the origins of lupus has been discovered. In those with systemic lupus erythematosus, B cells are abnormally activated. This results in the production of antibodies which react against the patient's own tissue, causing a range of symptoms including rashes, joint pain, and fatigue.

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Featured Neurology Neuroscience

·June 12, 2019·4 min read

Women caught in a pickle by their own immune systems

Pregnancy Compensation Hypothesis may explain why women are more prone to developing autoimmune diseases, like multiple sclerosis and lupus, than men.

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Featured Neurology Neuroscience Open Neuroscience Articles

·May 29, 2019·4 min read

New compounds could be used to treat autoimmune disorders

Researchers have developed small molecules that inhibit one of the main enzymes implicated in autoimmune response. The research could lead to potential new medications for a range of autoimmune diseases.

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Featured Genetics Neurology Neuroscience Open Neuroscience Articles Psychology

·May 26, 2019·6 min read

Autoimmune disease and stress: Is there a link?

Researchers consider why those with autoimmune diseases are more likely to have a previous diagnosis of stress-related disorders.

Featured Genetics Neurology Neuroscience Open Neuroscience Articles

·May 17, 2019·3 min read

Groundbreaking genetic discovery shows why Lupus develops

Rare gene variants BLK and BANK1 are present in a substantial percentage of people with Lupus. The genetic variants suppress 1RF5 and type-1 1Fn in B cells, causing dysfunction in the immune cells.

Featured Genetics Neurology Neuroscience Open Neuroscience Articles Psychology

·May 14, 2019·4 min read

How stressed-out gut bacteria may trigger autoimmune response

Chronic social stress in mice induces the expression of virulent genes in the gut microbiota. The altered microbiota increases the presence of effector T helper cells in the lymph nodes and induces myelin autoreactive cells. Exposure to chronic stress, therefore, may increase the risk of developing autoimmune diseases for some individuals with a susceptibility.

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