Projection neurons have been implicated in the progression of multiple sclerosis. A new study reports projection neurons are damaged by immune cells. This damage could contribute to both atrophy and cognitive changes associated with the disease.
Intrusive T cells have been discovered in the brain's neurogenic niches of older mice and humans. Findings suggest the T cells impair neurogenesis.
Maternal exposure to infection prior to pregnancy can transfer into life long cellular immunity in infants who are breastfed.
Blocking VCAM1 increased neurogenesis, and reduced microglia reactivity in the hippocampus of older mice.
Using mouse models, researchers have developed a comprehensive map of the brain's immune cells. The study found microglia in the choroid plexus showed a similar activation state as microglia that come into contact with Amyloid deposits.
The chemical probe CDr20 can label microglia in living cells, researchers report.
NASA scientists have published the results of the Kelly Twin Study, which revealed how the body adapts to life in space, compared to life on Earth. The findings revealed that, in space, telomeres are unexpectedly longer, the immune system responds appropriately, and variability in gene expression alters.
Researchers report transplanting bone marrow from young mice to older mice helps to preserve memory and learning skills. If the findings can be replicated in humans, researchers believe new therapies can be devised to help combat disorders associated with brain aging.
A new neuroimaging study reveals 12 people with documented post-treatment Lyme disease syndrome have an elevation of a chemical marker associated with neuroinflammation. The findings could help develop new treatments for the pain, fatigue and brain fog associated with PTLDS.
Studying animal models, researchers have identified previously unknown types of immune cells that are present in the brains of those with multiple sclerosis.
Using CRISPR gene editing, researchers mapped important genes for helping T helper cells. The findings could help generate new treatments to activate the immune system against infection and to attack tumor cells.
Researchers report therapeutic activation of the TREM2 gene during the early stages of Alzheimer's disease may help to counteract the formation of amyloid beta protein aggregates.
