Projection neurons have been implicated in the progression of multiple sclerosis. A new study reports projection neurons are damaged by immune cells. This damage could contribute to both atrophy and cognitive changes associated with the disease.
Using CRISPR gene editing, researchers mapped important genes for helping T helper cells. The findings could help generate new treatments to activate the immune system against infection and to attack tumor cells.
Maternal exposure to infection prior to pregnancy can transfer into life long cellular immunity in infants who are breastfed.
Examining postmortem brains of ASD patients, researchers discover an accumulation of immune cells surrounding blood vessels in the brain. They also found blebs accumulating around blood vessels that contained astrocyte debris. The findings suggest autism may be an autoimmune disorder.
APOE4 increases the inflammatory response of human microglia while reducing cellular migration. The gene also impairs the metabolic activity of the immune cells. The findings show APOE4 has a profound impact on the basic functions of microglia.
Researchers have identified a protein that could be leveraged to help microglia in the brain stave off Alzheimer's and other neurodegenerative diseases.
According to researchers, mast cells play an important role in determining whether an animal's sexual behavior will be more typical of a male or a female as they mature. Chemically stimulating mast cells in newborn female mice resulted in them acting more like males as adults.