APOE4 increases the inflammatory response of human microglia while reducing cellular migration. The gene also impairs the metabolic activity of the immune cells. The findings show APOE4 has a profound impact on the basic functions of microglia.
Researchers have discovered lymphatic vessels carry previously unknown messages from the brain to the immune system that triggers multiple sclerosis. Blocking the messages may provide new treatment options for the disease.
Maternal exposure to infection prior to pregnancy can transfer into life long cellular immunity in infants who are breastfed.
Microglia may play a significant role in disrupting neurogenesis in those with Alzheimer's disease. When mice were given drugs which caused microglial cells to die, neurogenesis returned to normal.
Researchers report therapeutic activation of the TREM2 gene during the early stages of Alzheimer's disease may help to counteract the formation of amyloid beta protein aggregates.