Female mice exposed to a high-fat diet have limited hippocampal neurogenesis. The findings may explain why women are at higher risk of developing dementia than men.
Chronic stress causes autophagy in adult hippocampal neural stem cells. This results in a decline of hippocampal neurogenesis. Cognitive deficits and mood disorders that arise as a result of chronic stress are a result of autophagic death of hippocampal neural stem cells.
Hippocampal neurogenesis continues to occur well into old age, and in those with Alzheimer's disease. Researchers found evidence of neurogenesis in people up to the age of 99. While neurogenesis continues to occur in those with Alzheimer's disease, it is significantly reduced compared to those who have normal cognitive function.
A new paper looks at the controversies surrounding adult neurogenesis.
Researchers report that following a stroke, the production of new neurons in the hippocampus fail to develop correctly. However, intervening in the production of these neurons could help mitigate memory problems experienced by those who suffer a stroke.
Researchers report exercise can promote adult hippocampal neurogenesis and improve cognition in mouse models of Alzheimer's disease. The study identifies ways to mimic the beneficial effects of experience through pharmacological and gene therapy.
UNC researchers have identified a brain circuit that runs from near the front of the brain to the hippocampus that helps to control neurogenesis.
A natural red pigment that is abundant in salmon and crustaceans appears to promote hippocampal neurogenesis, a new study reports.
Researchers discover how parvalbumin-expressing interneurons, which usually limits stem cell activity, can also encourage the survival of the stem cells' progeny.
Researchers discover hippocampal neurogenesis occurs daily in adult humans.