People with ALS have 2.5-fold higher levels of arachidonic acid, a lipid commonly found in fatty parts of meat and fish that spurs on inflammatory process, in their spinal motor cells than people without the disease. Treatment with caffeic acid, an anti-inflammatory compound naturally found in coffee, tea, and tomatoes, reduced some of the symptoms associated with ALS, and extended lifespan in animal models.
Researchers discover an important function of gamma-secretase in cells that is critical for lipid homeostasis in the brain.
The loss of fat metabolizing protein PPARalpha in the hippocampus can lead to dementia, a new study finds.