Summary: An artificial neural network has identified a potential mechanism for the impaired decision-making often seen in schizophrenia patients, which involves the reduced activity of NMDA receptors.
Study implicated hippocampal neurons in our ability to make educated guesses.
Study identifies neurons in command of guiding adaptive behaviors.
Neurons in the medial prefrontal cortex respond more to loss than to gain. Avoidance of risk-taking is affected by an area of the hippocampus that is associated with memory and anxiety. The findings suggest a close relationship between memory processing and decision making when risk is present, especially in stressful situations. The fresh insights might help guide new psychiatric therapies for disorders marked by excessive avoidance, such as anxiety, and depression, and also mania and addiction, where excessive risk-taking is a common feature.
Synchronized activity between the ventromedial prefrontal cortex and temporoparietal junction improves learning and decision-making when people try to avoid harming others.
Neuroimaging study reveals social learning is represented in the anterior cingulate cortex, while direct learning is represented in the ventromedial prefrontal cortex. The two areas both interact with the striatum, which helps compute both reward prediction error and social prediction error.
Animals slowly shift their likelihood of detecting stimulus changes over ten minutes. Researchers found the activity of neural populations from the V4 visual area and prefrontal cortex slowly drifted together with the behavioral fluctuations. The slow drift acts as an impulsivity signal.