Daily release of glucocorticoids depends on coordination between the clock gene and activity rhythms of neurons within two parts of the hypothalamus.
New genetic findings related to circadian rhythm could have implications for humans, animals, and even plant life.
Researchers reveal the role hundreds of miRNAs appear to play in modulating circadian rhythm.
Two small molecules, KL101 and TH301, are the first compounds that selectively target circadian clock components CRY1 and CRY2.
Deleting the circadian rhythm-associated BMAL1 gene in animal models, researchers discovered tissue continued to follow a 24-hour rhythm, even in the absence of external stimuli that can influence the cycle.
Study reveals how certain genetic mutations can shorten the timing of the circadian clock, making some people extreme "morning larks" because their internal clock operates on a 20-hour cycle, as opposed to a 24-hour cycle.
Chronobiologists warn changing to daylight savings can have serious effects on both brain and general health. The change in time during spring was linked to a 24% increase in severe cardiovascular events in women. Researchers also noted the sudden change in time alters circadian rhythms, reduces the production of natural melatonin, impacts cognitive function, and may also foster tumor growth.