circadian clock

·April 1, 2020

The discovery of new compounds for acting on the circadian clock

Two small molecules, KL101 and TH301, are the first compounds that selectively target circadian clock components CRY1 and CRY2. Read More

Featured Genetics Neuroscience

·February 19, 2020

Bmal1 gene is not an essential regulator of circadian rhythms

Deleting the circadian rhythm-associated BMAL1 gene in animal models, researchers discovered tissue continued to follow a 24-hour rhythm, even in the absence of external stimuli that can influence the cycle. Read More

Featured Neuroscience Open Neuroscience Articles

·February 18, 2020

Time of day affects global brain fluctuations

The strength of the brain's global signal fluctuation decreases as the day progresses. Read More

This shows a clock and the structure of CK1

Featured Genetics Neuroscience Open Neuroscience Articles

·February 13, 2020

Molecular switch mechanism explains how mutations shorten biological clocks

Study reveals how certain genetic mutations can shorten the timing of the circadian clock, making some people extreme "morning larks" because their internal clock operates on a 20-hour cycle, as opposed to a 24-hour cycle. Read More

This shows two clocks set one hour apart

Brain Cancer Featured Neurology Neuroscience

·January 21, 2020

Chronobiologists warn of health risks linked to daylight saving

Chronobiologists warn changing to daylight savings can have serious effects on both brain and general health. The change in time during spring was linked to a 24% increase in severe cardiovascular events in women. Researchers also noted the sudden change in time alters circadian rhythms, reduces the production of natural melatonin, impacts cognitive function, and may also foster tumor growth. Read More

This is a drawing from a Sleeping Beauty book

Featured Genetics Neuroscience

·January 15, 2020

Beauty sleep could be real, say body clock biologists

Study shows how circadian clock mechanisms boost our ability to maintain our bodies when we are most active. Read More

Featured Genetics Neuroscience Open Neuroscience Articles

·January 7, 2020

Removing body clock gene protects mice against pneumonia

Removing BMAL1, a gene commonly associated with circadian rhythm, makes macrophages more effective and the body more resistant to pneumonia. Read More

This shows a sad looking woman sitting in a forest with bare trees and leaves on the ground

Featured Neuroscience Psychology

·November 2, 2019

Seasonal Affective Disorder Impacts 10 Million Americans. Are You One of Them?

Seasonal affective disorder (SAD) affects over 10 million people in the US. Find out the symptoms and treatment options available. Read More

This shows a drawing of a mouse wearing sunglasses and covered in clocks

Featured Neuroscience Open Neuroscience Articles

·October 17, 2019

Skin keeps time independent of the brain

Neuropsin is expressed in the hair follicles of mice and synchronizes the skin's circadian clock, independent of the brain or eyes. Read More

Featured Neurology Neuroscience

·September 18, 2019

How sleepless nights compromise the health of your gut

Study reveals the function of specific immune cells, well documented as playing a significant role in gut health, is directly controlled by our circadian clock. Read More

Brain Cancer Featured Neurology Neuroscience

·August 27, 2019

Researchers take aim at circadian clock in deadly brain cancer

Glioblastoma stem cells' circadian clocks ramp up the cells' metabolism, making them stronger, more resistant to treatment, and able to divide and multiply more rapidly. By targeting the stem cells with a small molecule drug, researchers found mice models lived longer and their tumors shrank. Read More