Two small molecules, KL101 and TH301, are the first compounds that selectively target circadian clock components CRY1 and CRY2. Read More
Deleting the circadian rhythm-associated BMAL1 gene in animal models, researchers discovered tissue continued to follow a 24-hour rhythm, even in the absence of external stimuli that can influence the cycle. Read More
The strength of the brain's global signal fluctuation decreases as the day progresses. Read More
Study reveals how certain genetic mutations can shorten the timing of the circadian clock, making some people extreme "morning larks" because their internal clock operates on a 20-hour cycle, as opposed to a 24-hour cycle. Read More
Chronobiologists warn changing to daylight savings can have serious effects on both brain and general health. The change in time during spring was linked to a 24% increase in severe cardiovascular events in women. Researchers also noted the sudden change in time alters circadian rhythms, reduces the production of natural melatonin, impacts cognitive function, and may also foster tumor growth. Read More
Study shows how circadian clock mechanisms boost our ability to maintain our bodies when we are most active. Read More
Removing BMAL1, a gene commonly associated with circadian rhythm, makes macrophages more effective and the body more resistant to pneumonia. Read More
Seasonal affective disorder (SAD) affects over 10 million people in the US. Find out the symptoms and treatment options available. Read More
Neuropsin is expressed in the hair follicles of mice and synchronizes the skin's circadian clock, independent of the brain or eyes. Read More
Study reveals the function of specific immune cells, well documented as playing a significant role in gut health, is directly controlled by our circadian clock. Read More
Glioblastoma stem cells' circadian clocks ramp up the cells' metabolism, making them stronger, more resistant to treatment, and able to divide and multiply more rapidly. By targeting the stem cells with a small molecule drug, researchers found mice models lived longer and their tumors shrank. Read More
Advanced sleep phase may affect as many as one in 300 people, and may be the result of a genetic trait. Read More
