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Cdk5

·April 13, 2023·6 min read

A New Peptide May Hold Potential as an Alzheimer’s Treatment

Researchers say a peptide that blocks the hyperactive version of the CDK5 enzyme reduces neurodegeneration and DNA damage in mouse models of Alzheimer's disease. Animals treated with the peptide showed an improved ability to perform learning tasks.

Featured Neuroscience Psychology

·May 20, 2022·3 min read

Novel Preclinical Drug Could Have Potential to Combat Depression, Brain Injury, and Cognitive Disorders

A preclinical drug that inhibits the kinase enzyme Cdk5 may have the potential to treat depression, brain injuries, and disorders associated with cognitive impairment.

Featured Genetics Neuroscience

·December 9, 2019·2 min read

The genetic signature of memory

Cortical and subcortical memory regions exhibit distinct genetic signatures that reflect potential differences in health and disease.

Featured Genetics Neurology Neuroscience

·August 27, 2019·4 min read

High-fat diet in utero protects against Alzheimer’s later

High-fat diets during pregnancy may protect the developing brain from Alzheimer's in those with genetic risk factors.

Featured Genetics Neuroscience

·January 17, 2019·3 min read

Epigenetics Contributes to Male and Female Differences in Fear Memories

A new mouse study reveals males recall fearful memories better than females. Researchers attribute the difference to the gene Cdk5, which has previously been implicated in creating fear memories and stress behaviors. The study reports Cdk5 is naturally activated in males, but not females.

Featured Neurology Neuroscience Open Neuroscience Articles

·January 2, 2019·2 min read

Hyperactive Immune System Implicated in Aging Brain Disorders

According to a new study, the immune system may play a critical role in damage associated with neurodegenerative disorders such as Alzheimer's disease and ALS. The study reports altering Cdk5 results in the death of dopamine neurons and slowed autophagy.