Brain mapping study reveals memory engrams are widely distributed throughout the brain, including among regions not previously realized.
Floods of calcium that originate from hippocampal neurons can also boost learning, a new study reports.
Researchers have uncovered neural circuitry that allows the CA1 region of the hippocampus to communicate with its counterpart in the opposite hemisphere despite there being no connection between them.
Researchers identified specific receptors for acetylcholine that reroute information flow through memory circuits in the hippocampus. The findings could have implications for the development of drugs to help enhance or protect memory from diseases associated with cognitive decline.
Findings shed light on the mechanisms underlying brain damage in microgravity.
Researchers observed hippocampal place cell changes in animal experiments of cue-poor and cue-rich spatial environments. The findings have implications for the treatment of brain disorders and the development of new AI technologies.
Pyramidal cells in the CA2 region of the hippocampus are responsible for storing critical timing information.
Astrocytes, not microglia, are responsible for constantly eliminating unnecessary and excessive adult synaptic connections in response to brain activity.
GABAergic interneuron excitation is essential for network activity in the hippocampus of the fetal brain.
In mouse models of Alzheimer's disease, active neurons still encode memory, and a group of active neurons encodes novel environmental information. The signal of the novelty containing neurons causes a superimposition disturbing the signal of memory encoding neurons.
Hippocampal neurons that store abstract memories of prior experiences activate when new, but similar events take place.
Cognitive challenges trigger a slight oxygen deficit in hippocampal pyramidal neurons. This increases the production of erythropoietin (Epo) and its receptors in the active neurons, stimulating neighboring precursor cells to form new neurons and enhancing connectivity.
