GABAergic interneuron excitation is essential for network activity in the hippocampus of the fetal brain. Read More
In mouse models of Alzheimer's disease, active neurons still encode memory, and a group of active neurons encodes novel environmental information. The signal of the novelty containing neurons causes a superimposition disturbing the signal of memory encoding neurons. Read More
Hippocampal neurons that store abstract memories of prior experiences activate when new, but similar events take place. Read More
Cognitive challenges trigger a slight oxygen deficit in hippocampal pyramidal neurons. This increases the production of erythropoietin (Epo) and its receptors in the active neurons, stimulating neighboring precursor cells to form new neurons and enhancing connectivity. Read More
Hippocampal neurons involved in Pavlovian learning shift their behavior and become more synchronized when a memory is being formed. The findings shed new light on the neurobiological mechanisms of memory and learning. Read More
A new neuroimaging study reveals sex-based differences in the development of the hippocampus and amygdala. The findings may shed light on sex-based differences in the emergence of mental health disorders the occur during adolescence and early adulthood. Read More
A new study implicated interneurons and pyramidal cells in the ability of a seizure to spread through the brain. Read More
A newly identified neural network in the hippocampal formation plays a critical role in memory and object-location learning. The findings are highly relevant to learning and memory disorders, including Alzheimer's disease. Read More
A lack of oxygen as a result of preterm birth does not cause hippocampal neurons to die but does impair hippocampal development. Hypoxia causes hippocampal cells to fail to mature normally, causing a reduction in long-term potentiation and impaired learning. Read More
Stable memories are encoded by teams of neurons firing in synchrony, providing redundancy that enables the memory to persist over time. Read More
Enhanced reactivation of negative memory engrams may be an important cellular mechanism behind the cognitive symptoms of depression. Read More
Hippocampal neurons become longer and stronger following a period of sleep deprivation. The study supports the hypothesis that sleep may weaken synapses, which are strengthened from learning, allowing for learning to occur after waking. Read More
