c9ASO, an investigational ASO drug, targets the TDP-43 protein, reducing its buildup and decreasing neurological decline associated with ALS and FTD. Read More
Study reveals why some people with ALS are prone to developing autoimmune diseases. A genetic mutation that decreases the expression of C9orf72 causes the stimulation of interferon genes (STING) protein to become hyperactive. The hyperactivity leads to increased production of interferons. This can lead to systemic inflammation and the development of autoimmune diseases. Read More
Study reveals a new gut-brain connection in amyotrophic lateral sclerosis (ALS). The gut microbiome could influence the severity of the neurodegenerative disease. Altering the bacteria in the gut may prevent or improve symptoms of ALS. Read More
Researchers discovered increased inflammatory activity in a subgroup of patients with frontotemporal dementia. The increased inflammation was indicated by elevated levels of cytokines known to increase inflammatory response and decreased levels of IL-10, which reduces inflammation. The inflammation was associated with Parkinsonism's symptoms and rapid cognitive and functional decline. The study also revealed patients with FTD are less likely to develop cancer. Read More
Researchers have identified the normal function of C9orf72, a gene commonly implicated in ALS and FTD. Read More
Researchers reveal a small region of Ataxin-2, a protein implicated in long term memory, may drive the progression of ALS. Read More
Using CRISPR, researchers have identified a new set of genes that may be implicated in both ALS and frontotemporal dementia. Read More
Researchers report the C9ORF72 genetic mutation can lead to toxicity in neurons, causing 10 percent of all ALS cases and 10 percent of FTD cases. Read More
Researchers reveal a repeat element in the DNA of C9orf72 gene becomes toxic when faced with starvation, toxins and viral infection. Read More
Researchers believe a newly discovered mechanism may contribute to cell death in people suffering from ALS and dementia. Read More
Researchers report they have identified two regions of a mouse brain where a gene implicated in ALS is expressed. Read More
Researchers report the most common genetic mutation associated with ALS plays an important role in not only the nervous system, but also the blood and immune systems. Read More
