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C9ORF72

Featured Genetics Neurology Neuroscience

·November 22, 2022·5 min read

RNA-Targeting Strategy to Repair Genetic Cause of ALS and Dementia Developed

A novel compound eliminates disease-causing segments of RNA associated with ALS and dementia, and restores the health of neurons in mouse models.

Featured Genetics Neurology Neuroscience

·July 8, 2021·4 min read

ALS: Study Shows Role of Brain’s Immune Cells

Hyperactive microglia immune cells may play a significant role in the development of ALS, researchers report.

Featured Genetics Neurology Neuroscience

·June 16, 2021·2 min read

A Distinctive Inflammatory Signature Found in a Genetic Form of ALS

Researchers found an increased inflammatory signal in patients with the C90rf72 subtype of ALS. The increased inflammatory biomarkers could be found in peripheral serum tests.

This shows a woman doing crossfit exercise

Featured Genetics Neurology Neuroscience Open Neuroscience Articles

·June 12, 2021·6 min read

Frequent Strenuous Exercise Increases the Risk of Developing ALS in Certain People

Researchers have identified a causal link between strenuous exercise and ALS in people with genetic risk factors for the neurodegenerative disease. The study reports intense physical exercise contributes to motor neuron injury in those susceptible to ALS.

Featured Neurology Neuroscience Open Neuroscience Articles

·September 8, 2020·5 min read

Investigational Drug Stops Toxic Proteins Tied To ALS

c9ASO, an investigational ASO drug, targets the TDP-43 protein, reducing its buildup and decreasing neurological decline associated with ALS and FTD.

Featured Genetics Neurology

·August 20, 2020·5 min read

Autoimmune Diseases in ALS Patients Linked to Genetic Mutation

Study reveals why some people with ALS are prone to developing autoimmune diseases. A genetic mutation that decreases the expression of C9orf72 causes the stimulation of interferon genes (STING) protein to become hyperactive. The hyperactivity leads to increased production of interferons. This can lead to systemic inflammation and the development of autoimmune diseases.

Featured Neurology Neuroscience

·May 15, 2020·4 min read

Gut microbiome influences ALS outcomes

Study reveals a new gut-brain connection in amyotrophic lateral sclerosis (ALS). The gut microbiome could influence the severity of the neurodegenerative disease. Altering the bacteria in the gut may prevent or improve symptoms of ALS.

Featured Genetics Neurology Neuroscience Open Neuroscience Articles

·October 16, 2019·4 min read

Frontotemporal dementia is associated with alterations in immune system function

Researchers discovered increased inflammatory activity in a subgroup of patients with frontotemporal dementia. The increased inflammation was indicated by elevated levels of cytokines known to increase inflammatory response and decreased levels of IL-10, which reduces inflammation. The inflammation was associated with Parkinsonism's symptoms and rapid cognitive and functional decline. The study also revealed patients with FTD are less likely to develop cancer.