Using neurons created from iPS cells derived from people with ALS, researchers develop a new drug which appears to halt the impact of the genetic mutations in some forms of ALS and dementia.
Researchers discover how a genetic code variation in the C9orf72 gene alters the shape of DNA, making cells more vulnerable to stress and apoptosis.
Researchers found an increased inflammatory signal in patients with the C90rf72 subtype of ALS. The increased inflammatory biomarkers could be found in peripheral serum tests.
A new study points to a potential new target to treat neurodegenerative diseases.
Hyperactive microglia immune cells may play a significant role in the development of ALS, researchers report.
Study reveals why some people with ALS are prone to developing autoimmune diseases. A genetic mutation that decreases the expression of C9orf72 causes the stimulation of interferon genes (STING) protein to become hyperactive. The hyperactivity leads to increased production of interferons. This can lead to systemic inflammation and the development of autoimmune diseases.
Using CRISPR, researchers have identified a new set of genes that may be implicated in both ALS and frontotemporal dementia.
Researchers have identified a causal link between strenuous exercise and ALS in people with genetic risk factors for the neurodegenerative disease. The study reports intense physical exercise contributes to motor neuron injury in those susceptible to ALS.
Researchers discovered increased inflammatory activity in a subgroup of patients with frontotemporal dementia. The increased inflammation was indicated by elevated levels of cytokines known to increase inflammatory response and decreased levels of IL-10, which reduces inflammation. The inflammation was associated with Parkinsonism's symptoms and rapid cognitive and functional decline. The study also revealed patients with FTD are less likely to develop cancer.
Researchers reveal a repeat element in the DNA of C9orf72 gene becomes toxic when faced with starvation, toxins and viral infection.
Study reveals a new gut-brain connection in amyotrophic lateral sclerosis (ALS). The gut microbiome could influence the severity of the neurodegenerative disease. Altering the bacteria in the gut may prevent or improve symptoms of ALS.
Immune cells appear to play a direct role in the development of ALS, a new study reports.
