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C9ORF72

This is a cross section MRI of a patient with ALS.

Featured Genetics Open Neuroscience Articles

·October 16, 2013·6 min read

‘Individualized’ Therapy for the Brain Targets Specific Gene Mutations Causing Dementia and ALS

Using neurons created from iPS cells derived from people with ALS, researchers develop a new drug which appears to halt the impact of the genetic mutations in some forms of ALS and dementia.

The image is an autopsy specimen of a patient with frontotemporal dementa.

Featured Genetics

·October 25, 2013·5 min read

Lou Gehrig’s Disease: From Patient Stem Cells to Potential Treatment Strategy in One Study

Researchers create neurons from the skin cells of ALS patients in order to "treat" a gene defect in a dish.

The image shows frontotemporal degeneration in the brain.

Featured Neurology Open Neuroscience Articles

·October 30, 2013·3 min read

RNA Build Up Linked to Dementia and Motor Neuron Disease

Researchers have identified a new toxic entity associated with genetically inherited forms of frontotemporal dementia and motor neuron disease.

This image shows a motor neuron which was created from stem cells.

Featured Genetics

·March 6, 2014·4 min read

3D Changes in DNA May Lead to a Genetic Form of ALS

Researchers discover how a genetic code variation in the C9orf72 gene alters the shape of DNA, making cells more vulnerable to stress and apoptosis.

The image shows the brain of an adult fruit fly.

Featured Genetics Neurology

·August 12, 2014·2 min read

Toxic Proteins Damage Nerve Cells

Researchers discover how a specific genetic mutation leads to neuronal damage associated with ALS and frontotemporal dementia.

Scientists created a mouse model of ALS and FTD caused by mutations in the C9ORF72 gene. Credit: Courtesy of Petrucelli lab, Mayo Clinic, Jacksonville, Fla.

Featured Genetics

·May 22, 2015·4 min read

Scientists Create Mice with a Major Genetic Cause of ALS and FTD

Researchers believe mouse could provide a new platform for testing treatments for several neurodegenerative diseases.

This shows neurons created from an ALS patient.

Featured Genetics Neurology

·August 26, 2015·6 min read

RNA Blocked Pathways May Initiate ALS and Dementia

According to new research, the C9orf72 mutation causes long strands of RNA to block specific pathways which usually move proteins into a cell's nucleus.

Image shows antibodies surrounding a healthy motor neuron.

Featured Neurology

·October 5, 2015·4 min read

Tracking a Key Piece of Dementia and ALS Puzzle

Findings provide new hope for treating ALS and FTD, researchers report.

Featured Genetics Neurology

·October 19, 2015·4 min read

ALS and Frontotemporal Dementia Linked to Nuclear Transport Problems

A new study points to a potential new target to treat neurodegenerative diseases.

Image shows a brain against a DNA double helix background.

Featured Genetics Neurology

·March 17, 2016·4 min read

Immune Cells Play Direct Role in Development of ALS

Immune cells appear to play a direct role in the development of ALS, a new study reports.

Featured Neurology

·July 15, 2016·4 min read

Reopening Avenues for Attacking ALS

Researchers report the most common genetic mutation associated with ALS plays an important role in not only the nervous system, but also the blood and immune systems.