brain organoids

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brain organoids

Autism Featured Genetics Neuroscience Open Neuroscience Articles

·May 2, 2022·5 min read

Gene Therapy Reverses Effects of Autism-Linked Mutation in Brain Organoids

A brain organoid study reveals how a genetic mutation associated with Pitt-Hopkins syndrome, a profound form of autism, disrupts neural development. Using gene-editing technology, researchers recovered the function of the TCF4 gene and effectively restored neural structure and function.

This shows a model of a head and a brain

Featured Neuroethics Neuroscience

·February 18, 2022·4 min read

The Ethics of Research on Conscious Artificial Brains

A new ethical framework proposes researchers should already assume brain organoids already have consciousness, rather than waiting for research to confirm they do.

Autism Featured Genetics Neuroscience

·February 2, 2022·6 min read

Different Autism Risk Genes, Same Effects on Brain Development

Three different autism risk genes affect similar aspects of neural formation and the same types of neurons in the developing human brain.

Featured Genetics Neuroscience Open Neuroscience Articles Psychology

·December 16, 2021·4 min read

‘Mini-Brains’ Provide Clues About Early Life Origins of Schizophrenia

Brain organoid study reveals multiple changes in brain cells during early embryonic development may contribute to schizophrenia later in life.

This shows a numerous different graphs from the study

Featured Neurology Neuroscience Neuroscience Videos

·November 2, 2021·2 min read

Mini-Brain Models Used in Hunt for Alzheimer’s Treatment

Brain organoids can be used to study molecular mechanisms that drive brain aging and neurodegenerative disorders. The mini-brains allow for the testing of molecules that could become potential therapeutic treatment options for neurodegenerative diseases.

Featured Neuroscience

·August 23, 2021·6 min read

Brain Organoids With Complex Neural Activity Developed

Newly developed brain organoids grown from stem cells showed organized waves of neural activity similar to that seen in living human brains.

This shows amyloid beta in a staining sample

Featured Neurology Neuroscience

·August 7, 2021·3 min read

Miniature Brain Models Developed to Study the Causes of Alzheimer’s and Test Drugs in Development

Researchers have developed a new brain organoid model to study the mechanistic causes of Alzheimer's disease and test dementia drugs currently in development.

Featured Neurology Neuroscience

·July 26, 2021·5 min read

Early Signs of Frontotemporal Dementia Found in Personalized Cerebral Organoids

Researchers recreated the damage seen in frontotemporal dementia in brain organoid models. The study reveals an experimental drug designed to treat Crohn's disease may help prevent neuron death associated with FTD.

Autism Featured Genetics Neuroscience Open Neuroscience Articles

·July 14, 2021·5 min read

Mini-Brain Study Shows How Environmental Risk Factors Can Amplify Genetic Risks for Autism

Using human stem cells to develop a brain organoid model, researchers were able to show exposure to a common pesticide synergizes with an autism-linked gene mutation. The study provides clear evidence that genetics and environment may combine to disrupt neurodevelopment.

Featured Genetics Neuroscience

·March 24, 2021·5 min read

How Humans Develop Larger Brains Than Other Apes

Using brain organoid models, researchers have identified how the brain grows much larger and has three times as many neurons, as the brains of chimpanzees and gorillas.

This shows a female scientist looking in a microscope

Featured Genetics Neuroscience

·February 22, 2021·4 min read

‘Mini Brain’ Organoids Grown in Lab Mature Much Like Infant Brains

Brain organoids, or mini-brains, created from human stem cells appear to develop in much the same way as a human brain. The organoids follow an internal clock that guides their maturation in sync with the timeline for human brain development.

Featured Genetics Neuroscience

·February 11, 2021·5 min read

How a Single Gene Alteration May Have Separated Modern Humans From Predecessors

By altering the NOVA1 gene, researchers were able to "Neanderthal-izes" a brain organoid model. Study reveals there is only a one gene difference between the modern human brain and that of our extinct ancestors.

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