Newly developed brain organoids grown from stem cells showed organized waves of neural activity similar to that seen in living human brains.
Researchers have developed a new brain organoid model to study the mechanistic causes of Alzheimer's disease and test dementia drugs currently in development.
Researchers recreated the damage seen in frontotemporal dementia in brain organoid models. The study reveals an experimental drug designed to treat Crohn's disease may help prevent neuron death associated with FTD.
Using human stem cells to develop a brain organoid model, researchers were able to show exposure to a common pesticide synergizes with an autism-linked gene mutation. The study provides clear evidence that genetics and environment may combine to disrupt neurodevelopment.
Brain organoids, or mini-brains, created from human stem cells appear to develop in much the same way as a human brain. The organoids follow an internal clock that guides their maturation in sync with the timeline for human brain development.
By altering the NOVA1 gene, researchers were able to "Neanderthal-izes" a brain organoid model. Study reveals there is only a one gene difference between the modern human brain and that of our extinct ancestors.
ApoE4, a gene associated with an increased risk of Alzheimer's disease, also appears to increase susceptibility and the severity of COVID-19. SARS-CoV-2, the virus responsible for coronavirus, increased susceptibility to COVID-19 in ApoE4 neurons and astrocytes in brain organoid models.
SARS-CoV-2, the virus responsible for COVID-19, can infect human neural progenitor cells and brain organoids. The findings back previous research, finding coronavirus can infect the human brain.
Researchers used hPSCs to grow an organoid that produces inhibitory neurons and plays a critical role in the early development of the cortex.