Brain organoids, or mini-brains, created from human stem cells appear to develop in much the same way as a human brain. The organoids follow an internal clock that guides their maturation in sync with the timeline for human brain development.
Researchers gain inspiration for creating tiny artificial brains, that can be used for cancer research, from an ancient Japanese art of flower arranging.
Newly developed brain organoids grown from stem cells showed organized waves of neural activity similar to that seen in living human brains.
Researchers recreated the damage seen in frontotemporal dementia in brain organoid models. The study reveals an experimental drug designed to treat Crohn's disease may help prevent neuron death associated with FTD.
By altering the NOVA1 gene, researchers were able to "Neanderthal-izes" a brain organoid model. Study reveals there is only a one gene difference between the modern human brain and that of our extinct ancestors.
Researchers used hPSCs to grow an organoid that produces inhibitory neurons and plays a critical role in the early development of the cortex.
Using human stem cells to develop a brain organoid model, researchers were able to show exposure to a common pesticide synergizes with an autism-linked gene mutation. The study provides clear evidence that genetics and environment may combine to disrupt neurodevelopment.
Researchers have developed a new brain organoid model to study the mechanistic causes of Alzheimer's disease and test dementia drugs currently in development.