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brain organoid

This shows a brain.

Featured Genetics Neurology Neuroscience

·April 10, 2025·3 min read

Mini-Brain Models Reveal a New Dementia-Linked Protein Pathway

Scientists have discovered a new protein pathway involved in neurodegeneration by studying “mini-brain” organoids made from patients with frontotemporal lobar degeneration (FTLD). They found that the protein GRAMD1B plays a crucial role in managing cholesterol and lipid balance within neurons—processes closely linked to Alzheimer’s and FTLD.

This shows a model of a brain.

Featured Genetics Neurology Neuroscience

·April 4, 2024·5 min read

Brain Organoids Illuminate TBI’s Link to Neurodegeneration

Researchers have advanced our understanding of how traumatic brain injuries (TBI) contribute to neurodegenerative diseases using lab-grown brain organoids. By simulating TBI in organoids derived from human stem cells, the team observed nerve cell death and pathological changes similar to those in TBI patients, particularly in proteins associated with ALS and dementia.

This shows neurons

Featured Neurology Neuroscience

·December 5, 2023·5 min read

Dopaminergic System Organoid Model Illuminates Parkinson’s and Addiction

Researchers developed a novel organoid model that mimics the human dopaminergic system, providing crucial insights into Parkinson's disease and the impact of chronic cocaine use. This study demonstrates the model's ability to replicate the structure, connectivity, and functionality of the dopaminergic system.

This shows a brain organoid

Featured Genetics Neuroscience Open Neuroscience Articles

·September 13, 2022·3 min read

The Gene to Which We Owe Our Big Brain

The ARHGAP11B gene played a critical role in the development of the human neocortex during evolution.

This shows a mini brain

Featured Neuroscience

·January 7, 2021·3 min read

Peeking Inside ‘Mini-Brains’ Could Boost Understanding of the Human Brain

Study reveals the detailed internal anatomy of mini-brains for the first time.

This shows an organoid

Featured Genetics Neuroscience Open Neuroscience Articles

·December 8, 2020·6 min read

‘SCOUT’ Helps Researchers Find, Quantify Significant Differences Among Organoids

SCOUT is a newly developed pipeline for clearing, labeling, 3D imaging, and analyzing cerebral organoids.

A mini brain organoid is shown.

Featured Genetics Neuroscience Open Neuroscience Articles

·March 8, 2019·2 min read

Increasingly Complex Mini-brains

Brazilian scientists produce brain organoids with primitive eyes using computational fluid dynamics.

Image shows a brain organoid.

Featured Genetics Neuroscience

·December 29, 2016·5 min read

Scientists Engineer Gene Pathway to Grow Brain Organoids With Surface Folding

Findings could help to identify cells affected by Zika virus, researchers report.