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brain organoid

Featured Genetics Neurology Neuroscience

·April 10, 2025·3 min read

Mini-Brain Models Reveal a New Dementia-Linked Protein Pathway

Scientists have discovered a new protein pathway involved in neurodegeneration by studying “mini-brain” organoids made from patients with frontotemporal lobar degeneration (FTLD). They found that the protein GRAMD1B plays a crucial role in managing cholesterol and lipid balance within neurons—processes closely linked to Alzheimer’s and FTLD.

Featured Genetics Neurology Neuroscience

·April 4, 2024·5 min read

Brain Organoids Illuminate TBI’s Link to Neurodegeneration

Researchers have advanced our understanding of how traumatic brain injuries (TBI) contribute to neurodegenerative diseases using lab-grown brain organoids. By simulating TBI in organoids derived from human stem cells, the team observed nerve cell death and pathological changes similar to those in TBI patients, particularly in proteins associated with ALS and dementia.

Featured Neurology Neuroscience

·December 5, 2023·5 min read

Dopaminergic System Organoid Model Illuminates Parkinson’s and Addiction

Researchers developed a novel organoid model that mimics the human dopaminergic system, providing crucial insights into Parkinson's disease and the impact of chronic cocaine use. This study demonstrates the model's ability to replicate the structure, connectivity, and functionality of the dopaminergic system.