Focusing attention on a neural pathway starting at the periaqueductal grey region of the midbrain, researchers made a novel discovery about how dopamine generates different pain responses in male and female mice. Findings indicate dopamine may reduce pain sensitivity in males, whereas, in females, dopamine helps focus attention elsewhere in the presence of pain. Read More
Pnoc neurons in the BNST trigger pupillary response and increase heart rate in response to anxiety and fear. Read More
Fear and anxiety share overlapping neural circuits. The findings contradict the popular belief that anxiety and fear are distinct emotions with different triggers and segregated brain circuits. Read More
Oxytocin produced in the BNST increased stress-induced social anxiety behaviors in mice. The findings shed light on why oxytocin can sometimes provoke anti-social effects. Read More
Study provides contrary evidence to existing theory, finding anxiety and fear reflect overlapping neural circuits. Read More
Strengthened amygdala pathways increase aggression in those who have experienced trauma. The findings could lead to new treatments for PTSD. Read More
Turning off kappa opioid receptors in the brain decreases the urge the binge drink. Findings suggest the kappa opioid receptor system is important not only for the negative state of withdrawal but also for driving binge drinking behaviors. Read More
Inhibitory inputs to the neural circuit between the dorsolateral bed nucleus of the stria terminalis (dlBNST) to the ventral tegmental area (VTA) increase when a person is in chronic pain. This alteration is mediated by enhanced corticotropin-releasing factor signaling within the dlBNST, leading to suppression of the mesolimbic dopaminergic system. The result is depressive mood and anhedonia associated with chronic pain. Read More
Neurons in the bed nucleus of the stria terminalis (BNST) appear to regulate food intake. The neurons appear to form part of a network that controls appetite loss in mice. Read More
Researchers have uncovered a mechanism in the BNST that senses the negative effects of alcohol and modulates the urge to drink. The study reports that when this mechanism doesn't function correctly, we lose the ability to recognize that we have had enough to drink. Read More
A new study reveals impulsive behaviors may be triggered when dopamine passes from the amygdala to the BNST. Read More
Researchers have identified two subpopulations of neurons in the BNST that connect to separate populations of neurons in the lateral hypothalamus which appear to drive two opposing emotional states; avoidance and reward seeking Read More