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BACE1

Brain Cancer Featured Neurology Neuroscience

·November 26, 2021·4 min read

Drug Designed for Alzheimer’s Disease May Hold Promise for Treating Glioblastoma

A class of drugs called BACE1 inhibitors, originally designed to treat Alzheimer's disease, shows potential for the treatment of glioblastoma brain cancer.

Featured Genetics Neurology

·November 19, 2020·5 min read

Genetic Link to Molecular Events That Precede Symptoms in Alzheimer’s Disease Found

Researchers have identified a molecular mechanism that disrupts the flow of enzymes in axons, results in the accumulation of amyloid plaques.

Featured Neurology

·January 15, 2019·3 min read

Stroke Drug May Also Prevent Alzheimer’s

Researchers report a new drug being developed to treat stroke patients may also have neuroprotective properties against Alzheimer's disease.

Featured Neurology Open Neuroscience Articles

·October 4, 2018·6 min read

Periodontal Disease Bacteria May Kick Start Alzheimer’s

A new mouse study reveals long term exposure to bacteria associated with periodontal disease causes neuroinflammation and neurodegeneration, leading to similar effects of Alzheimer's disease. Researchers report periodontal disease may be an initiator of Alzheimer's.

a brain with a drawing of a viral vector on top

Featured Genetics Neurology Open Neuroscience Articles

·June 21, 2018·10 min read

Viral Connection to Alzheimer’s: Herpes Virus Implicated in Alzheimer’s Disease

Researchers provide evidence that certain species of human herpesvirus contribute to the development of Alzheimer's disease. The study reports high levels of human herpesvirus 6A and 7 were found in brain samples showing signs of Alzheimer's neuropathology. The findings offer hints of the viral mechanisms that could trigger or exacerbate AD.

Featured Neurology

·April 9, 2018·3 min read

Overlapping Mechanisms in HIV Cognitive Disorders and Alzheimer’s

A new Journal of Neuroscience study reports elevated levels of BACE1, an enzyme associated with neuronal damage in Alzheimer's disease, were identified in postmortem brain samples of those with HIV.

Featured Neurology Open Neuroscience Articles

·February 14, 2018·3 min read

Researchers Successfully Reverse Alzheimer’s Disease: Mouse Study

Depleting BACE1 completely reverses the formation of amyloid plaques and improves cognitive function in mouse models of Alzheimer's disease, researchers report.