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autoimmune diseases

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The gut may be involved in the development of multiple sclerosis

Neuroscience News
Increased levels of Smad7 in T-cells is linked to multiple sclerosis-like symptoms in mice. In the intestines, the T-cells were more frequently activated and migrated to the central nervous system, where they triggered inflammation. Similar activation was seen in human patients with multiple sclerosis. The findings provide further evidence that multiple sclerosis may start in the intestines and spread via the CNS.... Read More...
FeaturedNeurologyNeuroscience4 min read
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Gut instincts: Researchers discover first clues on how gut health influences brain health

Neuroscience News
Mice bred to be germ-free, and those treated with antibiotics showed a significant reduction in the ability to learn that a threatening danger was no longer present. Sequencing the RNA of microglia in the brains of the animals reveals altered gene expression in the immune cells, which play a role in remodeling how neurons connect during the learning process. Restoring the gut microbiota reverse the learning problems.... Read More...
FeaturedNeuroscience6 min read
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Frontotemporal dementia is associated with alterations in immune system function

Neuroscience News
Researchers discovered increased inflammatory activity in a subgroup of patients with frontotemporal dementia. The increased inflammation was indicated by elevated levels of cytokines known to increase inflammatory response and decreased levels of IL-10, which reduces inflammation. The inflammation was associated with Parkinsonism's symptoms and rapid cognitive and functional decline. The study also revealed patients with FTD are less likely to develop cancer.... Read More...
FeaturedGeneticsNeurologyNeuroscienceOpen Neuroscience Articles5 min read
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Targeting certain rogue T cells prevents and reverses multiple sclerosis: Mouse study

Neuroscience News
TH17 cells produced increased amounts of SerpinB1, a protein implicated in multiple sclerosis symptoms. SerpinB1 cells were identified with antibodies targeting the CXCR6 surface protein. Using monoclonal antibodies to target CXCR6, the cells disappeared significantly, and the mice primed to develop MS did not develop the disease.... Read More...
FeaturedGeneticsNeurologyNeuroscience6 min read