Study reveals an association between signal detection theory, brain activation patterns, and subjective state fatigue. In those with multiple sclerosis, greater effects of fatigue were seen.
In the first year after a diagnosis of multiple sclerosis, 60% of patients experience fatigue, 50% experience pain, 47% have symptoms of depression, and 39% report increased anxiety. Researchers say urgent, non-pharmaceutical therapies should be provided for newly diagnosed MS patients to help reduce both pain and mental health symptoms.
In rheumatoid arthritis, inflammation in one joint is transmitted to other joints via the sensory neuron connections in the spinal cord, leading to inflammation in the other joints. Inflammation in one joint led to an increase in ATP in other joints, which triggered an increase of a signaling molecule that resulted in inflammation. Blocking the pathway reduced the spread of inflammation.
Women who experienced childhood trauma had an increased risk of developing multiple sclerosis later in life. The evidence suggests childhood abuse and trauma can alter the immune system and increase the risk of developing autoimmune diseases.
A study of monozygotic twins allowed researchers to discover which parts of immune dysfunction in multiple sclerosis were influenced by genetics, and which were influenced by environmental factors.
Around 25% of patients with multiple sclerosis have blood antibodies that bind to the Epstein-Barr virus and EBNA1, a protein made in the brain and spinal cord. Researchers say this is the first study to definitely show that the Epstein-Barr virus can cause multiple sclerosis in some patients.
Researchers have identified a link between multiple sclerosis and a decreased level of specific gut bacteria. Additionally, the study reveals those who consume more meat may be at increased risk of developing the autoimmune disorder.