autoimmune diseases

This is a DNA strand

12 genes at the root of multiple sclerosis identified

12 genes associated with familial multiple sclerosis have been identified. The findings provide a molecular rationale for the chronic inflammation, demyelination and neurodegeneration associated with MS. Identifying new genetic targets could help with the development of novel treatments to prevent multiple sclerosis in those with a genetic risk.... Read More...
This shows slides from the study

How stressed-out gut bacteria may trigger autoimmune response

Chronic social stress in mice induces the expression of virulent genes in the gut microbiota. The altered microbiota increases the presence of effector T helper cells in the lymph nodes and induces myelin autoreactive cells. Exposure to chronic stress, therefore, may increase the risk of developing autoimmune diseases for some individuals with a susceptibility.... Read More...
This shows VGLL3 expression in different skin samples

Skin discovery may help explain why women get autoimmune diseases far more often than men

Skin cells may hold the key to explaining why women are more prone to developing autoimmune diseases, such as lupus than men. Researchers found women have more VGLL3 in their skin cells than men. VGLL3 pushes the immune system into overdrive, resulting in the 'self-attacking' autoimmune response, the mouse study revealed. Findings strongly implicate VGLL3 as a pivotal catalyst in sex-based autoimmunity.... Read More...
This shows myelin on neurons

Study shows promise in repairing damaged myelin

A study in mouse models of multiple sclerosis demonstrates a compound called sobetirome promotes remyelination, and a derivative of the compound can penetrate the blood-brain barrier to enable a tenfold increase in infiltration to the CNS. Researchers are confident their research will translate from mice into humans, providing a new avenue of treatment for MS.... Read More...