antidepressant

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antidepressant

This shows a man holding his back in pain

·January 30, 2023·5 min read

How Ketamine Acts as Antidepressant in Chronic Pain

Chronic pain in mice activates Tiam1 in pyramidal neurons in the anterior cingulate cortex, increasing the number of dendritic spines and inducing synaptic plasticity. Ketamine's antidepressant effect in chronic pain is mediated by the drug blocking Tiam1-dependent maladaptive synaptic plasticity in ACC neurons.

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·May 25, 2022·3 min read

Using Ketamine to Find an Undiscovered Pathway in Depression

Ketamine treatment leads to an increase in IGF-1, which, in turn, produces an antidepressant effect.

This shows how NV-5138 affects dendrites

Featured Neuroscience Open Neuroscience Articles Psychology

·April 17, 2019·3 min read

New drug mimics benefits of ketamine for depression

NV-5138, a small molecule drug that mimics the action of ketamine, provides fast-acting antidepressant responses in rodent models of depression. The drug is currently undergoing Phase 1 testing in humans.

Featured Neuroscience Psychology

·October 19, 2018·2 min read

Aerobic Exercise has Antidepressant Treatment Effects

A new study reports aerobic exercise can have antidepressant effects for patients with major depressive disorder.

Featured Genetics Psychology

·September 2, 2016·4 min read

Common Genetic Variant Regulates the Mental Health Benefits of Exercise

Researchers report physical exercise failed to promote antidepressant-like effects in mice genetically engineered to express a human genetic variation in the gene BDNF.

Image shows the chemical structure of AMPA.

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·May 4, 2016·6 min read

Ketamine Lifts Depression via a Byproduct of Its Metabolism

A metabolite created as the body breaks down ketamine could hold the key to understanding its antidepressant action, a new study reports.

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·January 12, 2016·3 min read

Compound Delivers Antidepressant Effect Within Hours

Researchers report those addicted to cocaine may have difficulty controlling their addiction because of a 'back door' into the brain that circumvents their self control.