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amyloid fibrils

·October 25, 2024·4 min read

Pausing Amyloid Fibrils Offers New Alzheimer’s Insight

Researchers have identified a unique “paused state” in the growth of amyloid β fibrils, linked to Alzheimer’s disease, using high-speed atomic force microscopy. In this state, fibril growth is halted, allowing an antibody, 4396C, to bind and prevent further growth, opening a potential path to slow Alzheimer’s progression.

This shows the structure of the proteins

Featured Genetics Neurology Neuroscience

·April 23, 2022·5 min read

Unexpected Protein Could Play Role Frontotemporal Dementia

Amyloid fibrils in those with frontotemporal lobar degeneration (FTLD) contain a little-known protein called TMEM106B. Researchers speculate TMEM106B could be found to be the cause of FTLD.

Featured Neurology Neuroscience

·September 13, 2021·4 min read

Docking Peptides, Slow to Lock, Open Possible Path to Treat Alzheimer’s

Drugs that stabilize amyloid fibril "frustration" block further aggregation and could provide a new method to prevent the progression of Alzheimer's.

Featured Neurology Neuroscience

·June 15, 2020·4 min read

New indication of a link between Alzheimer’s and diabetes

A new high-resolution 3D model reveals strong similarities in fibril structures associated with Alzheimer's and type 2 diabetes.

Featured Neurology Neuroscience Open Neuroscience Articles

·August 11, 2019·5 min read

High-energy lasers could be used to treat Alzheimer’s disease in the future

Far-infrared free-electron lasers may be a new way in which we fight the effects of Alzheimer's disease. Researchers report the technology can break down protein aggregates associated with the disease deep within the brain.

Image shows a 3-D reconstruction of an amyloid fibril

Featured Neurology

·September 8, 2017·6 min read

Sharpest Image of Alzheimer’s Fibrils Shows Previously Unknown Details

Researchers have captured some of the sharpest images of Alzheimer's associated amyloid fibrils to date. The 3D structure of the fibrils displays some previously unknown structural details that researchers believe could help answer some important questions about the development of Alzheimer's disease.

Featured Neurology

·July 18, 2016·2 min read

How Proteins in the Brain Build Up Rapidly in Alzheimer’s

Researchers report they have discovered the mechanism that leads to the rapid build up of amyloid plaques in Alzheimer's disease.

Featured Neurology

·July 11, 2016·4 min read

Amyloid Probes Gain Powers in Search For Alzheimer’s Cause

A metallic molecule allows for real time motoring of amyloid beta plaques.

Featured Neurology

·June 10, 2016·4 min read

New Clues to Toxic Forms of Amyloid Beta in Alzheimer’s

Researchers made a subtle alteration to the amyloid beta protein. The change affect its aggregation behavior and stabilizes an intermediate form with enhanced toxicity.

Image shows Lewy bodies in a brain slice.

Featured Neurology

·March 14, 2016·3 min read

Method Identifies When Parkinson’s Proteins Become Toxic to Brain Cells

Researchers have identified the point at which proteins in the brain turn toxic during the decent into Parkinson's disease.

The image shows the molecular chaperone binding to amyloid beta.

Featured Genetics

·February 17, 2015·5 min read

Molecular Inhibitor Breaks Cycle That Leads to Alzheimer’s

A new study reports a molecular chaperone can inhibit a key stage in the development of Alzheimer's disease.

This is an image of ruthenium complex molecules.

Featured Neurology

·July 23, 2013·4 min read

New Clues Illuminate Alzheimer’s Roots

Researchers have discovered how synthetic molecules latch onto amyloid peptide fibrils. The discovery could help develop new therapies to halt Alzheimer's disease.

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amyloid fibrils

Pausing Amyloid Fibrils Offers New Alzheimer’s Insight

Unexpected Protein Could Play Role Frontotemporal Dementia

Docking Peptides, Slow to Lock, Open Possible Path to Treat Alzheimer’s

New indication of a link between Alzheimer’s and diabetes

High-energy lasers could be used to treat Alzheimer’s disease in the future

Sharpest Image of Alzheimer’s Fibrils Shows Previously Unknown Details

How Proteins in the Brain Build Up Rapidly in Alzheimer’s

Amyloid Probes Gain Powers in Search For Alzheimer’s Cause

New Clues to Toxic Forms of Amyloid Beta in Alzheimer’s

Method Identifies When Parkinson’s Proteins Become Toxic to Brain Cells

Molecular Inhibitor Breaks Cycle That Leads to Alzheimer’s

New Clues Illuminate Alzheimer’s Roots

Chronic Pain Linked to Neuron Overactivity in the Brainstem

New Autism Data Reveals Insights Into Profound Cases

Wellbeing May Help Protect Memory in Middle Age

Ketamine Plus Therapy Offers Lasting Relief for Severe Depression

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