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          amyloid fibrils

          This shows neurons.
          FeaturedNeurologyNeuroscience
          ·October 25, 2024·4 min read

          Pausing Amyloid Fibrils Offers New Alzheimer’s Insight

          Researchers have identified a unique “paused state” in the growth of amyloid β fibrils, linked to Alzheimer’s disease, using high-speed atomic force microscopy. In this state, fibril growth is halted, allowing an antibody, 4396C, to bind and prevent further growth, opening a potential path to slow Alzheimer’s progression.
          Read More
          This shows the structure of the proteins
          FeaturedGeneticsNeurologyNeuroscience
          ·April 23, 2022·5 min read

          Unexpected Protein Could Play Role Frontotemporal Dementia

          Amyloid fibrils in those with frontotemporal lobar degeneration (FTLD) contain a little-known protein called TMEM106B. Researchers speculate TMEM106B could be found to be the cause of FTLD.
          Read More
          This is a diagram from the study
          FeaturedNeurologyNeuroscience
          ·September 13, 2021·4 min read

          Docking Peptides, Slow to Lock, Open Possible Path to Treat Alzheimer’s

          Drugs that stabilize amyloid fibril "frustration" block further aggregation and could provide a new method to prevent the progression of Alzheimer's.
          Read More
          This shows the fibrils
          FeaturedNeurologyNeuroscience
          ·June 15, 2020·4 min read

          New indication of a link between Alzheimer’s and diabetes

          A new high-resolution 3D model reveals strong similarities in fibril structures associated with Alzheimer's and type 2 diabetes.
          Read More
          This shows two brains
          FeaturedNeurologyNeuroscienceOpen Neuroscience Articles
          ·August 11, 2019·5 min read

          High-energy lasers could be used to treat Alzheimer’s disease in the future

          Far-infrared free-electron lasers may be a new way in which we fight the effects of Alzheimer's disease. Researchers report the technology can break down protein aggregates associated with the disease deep within the brain.
          Read More
          Image shows a 3-D reconstruction of an amyloid fibril
          FeaturedNeurology
          ·September 8, 2017·6 min read

          Sharpest Image of Alzheimer’s Fibrils Shows Previously Unknown Details

          Researchers have captured some of the sharpest images of Alzheimer's associated amyloid fibrils to date. The 3D structure of the fibrils displays some previously unknown structural details that researchers believe could help answer some important questions about the development of Alzheimer's disease.
          Read More
          amyloid fibrils.
          FeaturedNeurology
          ·July 18, 2016·2 min read

          How Proteins in the Brain Build Up Rapidly in Alzheimer’s

          Researchers report they have discovered the mechanism that leads to the rapid build up of amyloid plaques in Alzheimer's disease.
          Read More
          Image shows amyloid fibrils.
          FeaturedNeurology
          ·July 11, 2016·4 min read

          Amyloid Probes Gain Powers in Search For Alzheimer’s Cause

          A metallic molecule allows for real time motoring of amyloid beta plaques.
          Read More
          Image shows amyloid fibrils.
          FeaturedNeurology
          ·June 10, 2016·4 min read

          New Clues to Toxic Forms of Amyloid Beta in Alzheimer’s

          Researchers made a subtle alteration to the amyloid beta protein. The change affect its aggregation behavior and stabilizes an intermediate form with enhanced toxicity.
          Read More
          Image shows Lewy bodies in a brain slice.
          FeaturedNeurology
          ·March 14, 2016·3 min read

          Method Identifies When Parkinson’s Proteins Become Toxic to Brain Cells

          Researchers have identified the point at which proteins in the brain turn toxic during the decent into Parkinson's disease.
          Read More
          The image shows the molecular chaperone binding to amyloid beta.
          FeaturedGenetics
          ·February 17, 2015·5 min read

          Molecular Inhibitor Breaks Cycle That Leads to Alzheimer’s

          A new study reports a molecular chaperone can inhibit a key stage in the development of Alzheimer's disease.
          Read More
          This is an image of ruthenium complex molecules.
          FeaturedNeurology
          ·July 23, 2013·4 min read

          New Clues Illuminate Alzheimer’s Roots

          Researchers have discovered how synthetic molecules latch onto amyloid peptide fibrils. The discovery could help develop new therapies to halt Alzheimer's disease.
          Read More
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          This shows a brain.

          Chronic Pain Linked to Neuron Overactivity in the Brainstem

          This shows DNA and a child's head.

          New Autism Data Reveals Insights Into Profound Cases

          This shows a happy older man.

          Wellbeing May Help Protect Memory in Middle Age

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          Ketamine Plus Therapy Offers Lasting Relief for Severe Depression

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