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Alzheimer’s disease

Featured Genetics Neurology Neuroscience Open Neuroscience Articles

·September 16, 2019·4 min read

Alzheimer’s disease risk gene APOE4 impairs function of brain immune cells

APOE4 increases the inflammatory response of human microglia while reducing cellular migration. The gene also impairs the metabolic activity of the immune cells. The findings show APOE4 has a profound impact on the basic functions of microglia.

Featured Genetics Neurology Neuroscience

·September 15, 2019·3 min read

How the eyes might be windows to the risk of Alzheimer’s disease

Adults with mild cognitive impairment (MCI), a precursor to Alzheimer's disease, have greater pupil dilation when taking cognitive tests than their cognitively normal peers. Task-evoked pupillary response may be a cost-effective, and low invasive screening test for those at genetic risk for Alzheimer's before the symptoms of the disease take hold.

Featured Neurology Neuroscience

·September 13, 2019·3 min read

What multilingual nuns can tell us about dementia

While being multilingual did not delay the onset of dementia for those at risk, nuns who spoke four or more languages were significantly less likely to develop dementia than those who spoke just one language.

Featured Neurology Neuroscience

·September 4, 2019·4 min read

‘Hunger Hormone’ Linked to Memory in Alzheimer’s Study

A study that used postmortem brain tissue samples from Alzheimer's patients and mouse models found the hunger hormone ghrelin is linked to cognitive impairments and memory loss associated with the disease.

Featured Neurology Neuroscience Open Neuroscience Articles

·September 3, 2019·4 min read

Diet’s effect on gut bacteria could play role in reducing Alzheimer’s risk

A modified Mediterranean-ketogenic diet can modulate the gut microbiome and metabolites associated with improvements in Alzheimer's disease biomarkers.

This shows the location of the brain networks

Featured Neurology Neuroscience

·September 2, 2019·3 min read

Map of broken brain networks shows why people lose speech in language-based dementia

Researchers have identified the location of dysfunctional brain networks that lead to impaired sentence production and word-finding in primary progressive aphasia (PPA). PPA can occur in those with neurodegenerative diseases, such as frontotemporal dementia and Alzheimer's disease. Mapping the networks allows clinicians to apply non-invasive brain stimulation to potentially improve speech in those with PPA.

Featured Genetics Neurology Neuroscience

·August 30, 2019·4 min read

Creation of new brain cells plays an underappreciated role in Alzheimer’s disease

Microglia may play a significant role in disrupting neurogenesis in those with Alzheimer's disease. When mice were given drugs which caused microglial cells to die, neurogenesis returned to normal.

Featured Genetics Neurology Neuroscience

·August 27, 2019·4 min read

High-fat diet in utero protects against Alzheimer’s later

High-fat diets during pregnancy may protect the developing brain from Alzheimer's in those with genetic risk factors.

Featured Neurology Neuroscience Open Neuroscience Articles

·August 24, 2019·4 min read

Think declining mental sharpness ‘just comes with age’? Think again

Age-related diseases and not age itself contributes to cognitive decline.

Featured Genetics Neurology Neuroscience

·August 23, 2019·6 min read

How ‘Australian’ mutation leads to Alzheimer’s disease

The 'Australian' familial genetic mutation, L723P, causes local unfolding of the C-terminal turn of the APP TM dominant helix. The findings suggest a mechanism of pathogenesis associated with the mutation.

Featured Genetics Neurology Neuroscience Open Neuroscience Articles

·August 22, 2019·4 min read

Carriers of Alzheimer’s genetic marker have greater difficulty harnessing past knowledge

Middle-aged people with the Alzheimer's related APOE4 gene have a harder time accessing recently acquired knowledge, even when they show no symptoms of memory decline.

Featured Neurology Neuroscience Open Neuroscience Articles

·August 21, 2019·3 min read

Link between brain immune cells and Alzheimer’s disease development identified

The brain's immune cells may contribute to the development of Alzheimer's disease. Turning off microglia in specific areas of the brain prevented the formation of amyloid plaques. The findings could help pave the way for new treatments for Alzheimer's.

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Alzheimer’s disease

Alzheimer’s disease risk gene APOE4 impairs function of brain immune cells

How the eyes might be windows to the risk of Alzheimer’s disease

What multilingual nuns can tell us about dementia

‘Hunger Hormone’ Linked to Memory in Alzheimer’s Study

Diet’s effect on gut bacteria could play role in reducing Alzheimer’s risk

Map of broken brain networks shows why people lose speech in language-based dementia

Creation of new brain cells plays an underappreciated role in Alzheimer’s disease

High-fat diet in utero protects against Alzheimer’s later

Think declining mental sharpness ‘just comes with age’? Think again

How ‘Australian’ mutation leads to Alzheimer’s disease

Carriers of Alzheimer’s genetic marker have greater difficulty harnessing past knowledge

Link between brain immune cells and Alzheimer’s disease development identified

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