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Alzheimer’s disease

Featured Neurology Neuroscience Psychology

·October 2, 2024·4 min read

Cannabis Pill Reduces Agitation in Alzheimer’s Patients by 30%

A new study reveals that dronabinol, a synthetic form of THC, can reduce agitation in Alzheimer’s patients by 30%. Unlike current medications, dronabinol showed fewer side effects, such as delirium or seizures, making it a safer alternative.

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Featured Neurology Neuroscience

·October 2, 2024·4 min read

Time of Day Affects Key Biomarkers for Alzheimer’s Diagnosis

New research shows that the time of day when blood samples are taken significantly impacts the levels of Alzheimer's biomarkers, including p-tau217, which is crucial for early diagnosis. Biomarker levels were found to be lowest in the morning and highest in the evening, indicating that timing could affect dementia diagnosis and monitoring.

Featured Genetics Neurology Neuroscience

·September 30, 2024·5 min read

Genetic Variants Linked to Alzheimer’s Trigger Inflammation in Females

Researchers have discovered that two genetic variants, APOE4 and TREM2 R47H, together cause a harmful inflammatory response in brain immune cells, particularly in females. This response leads to more severe brain damage, including tau protein clumps, which are linked to Alzheimer’s disease progression.

Featured Neurology Neuroscience

·September 30, 2024·5 min read

New Astrocyte Target for Alzheimer’s Therapy

Researchers have identified a novel therapeutic target for Alzheimer’s disease by focusing on astrocytes, non-neuronal brain cells involved in waste removal. They found that astrocytic autophagy clears amyloid-beta (Aβ) oligomers, toxic proteins in Alzheimer’s patients, and helps restore cognitive functions.

This shows a brain, tomatoes and carrots.

Featured Neurology Neuroscience

·September 26, 2024·3 min read

Food Compound May Extend Lifespan and Reduce Alzheimer’s Symptoms

arotenoid phytoene can extend the lifespan of the nematode Caenorhabditis elegans by up to 18.6% and slow paralysis linked to amyloid plaques, a hallmark of Alzheimer's disease. This study, which used phytoene extracts from microalgae, showed a reduction in plaque-related damage by up to 40%. These promising results pave the way for future studies to explore the mechanisms behind phytoene's protective effects. The findings highlight phytoene’s potential as a beneficial compound in food and cosmetic products for health and longevity.

Featured Neurology Neuroscience

·September 25, 2024·3 min read

Alzheimer’s Drug Faces Scrutiny Over Safety, Efficacy Concerns

The FDA-approved Alzheimer’s drug donanemab is under scrutiny due to concerns about its effectiveness and safety, according to an investigation. The study highlights multiple patient deaths during trials, design flaws, and the financial ties of panelists who recommended the drug's approval.

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Featured Neurology Neuroscience

·September 7, 2024·5 min read

Tau Levels Predict Memory Loss in Alzheimer’s

Alzheimer's disease (AD) progression varies based on the presence of tau and amyloid-beta (Aβ) proteins in the brain. Patients with high levels of both tau and Aβ experience rapid memory decline, while those with high Aβ but low tau show a slower progression. The research emphasizes that tau levels are crucial for diagnosing and managing AD effectively. This insight could lead to more personalized treatment strategies as biomarker technology advances.

Featured Neurology Neuroscience

·September 6, 2024·3 min read

Nighttime Light Pollution Linked to Higher Alzheimer’s Risk

A recent study has found a positive correlation between nighttime light pollution and the prevalence of Alzheimer’s disease (AD) in the United States. Researchers discovered that higher levels of light at night are associated with increased AD rates, particularly among individuals under the age of 65.

Featured Neurology Neuroscience

·September 4, 2024·5 min read

Novel Drug Shows Promise in Preventing Early Alzheimer’s Brain Changes

A recent study has shown that troriluzole can prevent early-stage brain changes in a mouse model of Alzheimer’s disease. The research demonstrated that troriluzole reduces harmful glutamate levels, preserving memory and cognitive function.

Featured Neurology Neuroscience

·August 30, 2024·5 min read

Tau May Protect Brain Cells from Oxidative Damage

Researchers have discovered that the Tau protein, often linked to neurodegenerative diseases like Alzheimer's, also has a protective role in the brain. Tau helps combat oxidative stress by aiding in the formation of lipid droplets in glial cells, which sequester toxic lipids and protect neurons.

This shows a person holding a brain model.

Featured Neurology Neuroscience

·August 25, 2024·6 min read

Blocking a Brain Pathway Reverses Memory Loss in Alzheimer’s

Blocking the kynurenine pathway, a regulator of brain metabolism, can restore cognitive function in lab mice with Alzheimer’s disease. The pathway is overactivated in Alzheimer’s, disrupting glucose metabolism and starving neurons of energy. By inhibiting this pathway, researchers improved memory and brain plasticity in mice, offering hope for new treatments in humans. IDO1 inhibitors, currently in cancer trials, could be repurposed for Alzheimer’s treatment.

Featured Neurology Neuroscience

·August 23, 2024·5 min read

Does Multiple Sclerosis Lower Dementia Risk?

Research has revealed that individuals with multiple sclerosis (MS) are significantly less likely to exhibit the molecular signs of Alzheimer’s disease, suggesting a protective element in MS that could inspire new Alzheimer's treatments. The study found that MS patients had 50% less amyloid plaque accumulation, a key indicator of Alzheimer’s, compared to non-MS individuals. This connection between MS and reduced Alzheimer's risk highlights potential immune-related mechanisms that may be leveraged for therapeutic strategies.

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Alzheimer’s disease

Cannabis Pill Reduces Agitation in Alzheimer’s Patients by 30%

Time of Day Affects Key Biomarkers for Alzheimer’s Diagnosis

Genetic Variants Linked to Alzheimer’s Trigger Inflammation in Females

New Astrocyte Target for Alzheimer’s Therapy

Food Compound May Extend Lifespan and Reduce Alzheimer’s Symptoms

Alzheimer’s Drug Faces Scrutiny Over Safety, Efficacy Concerns

Tau Levels Predict Memory Loss in Alzheimer’s

Nighttime Light Pollution Linked to Higher Alzheimer’s Risk

Novel Drug Shows Promise in Preventing Early Alzheimer’s Brain Changes

Tau May Protect Brain Cells from Oxidative Damage

Blocking a Brain Pathway Reverses Memory Loss in Alzheimer’s

Does Multiple Sclerosis Lower Dementia Risk?

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