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Alzheimer’s disease

This shows a person on a treadmill and neurons.

Featured Genetics Neurology Neuroscience

·June 13, 2025·5 min read

Exercise Rewires Alzheimer’s-Affected Brain Cells

Using cutting-edge RNA sequencing, researchers mapped how exercise affects specific brain cell types in a model of Alzheimer’s disease. They found that physical activity alters gene activity in microglia and a newly identified type of astrocyte linked to blood vessels, which may protect memory.

Featured Genetics Neurology Neuroscience

·June 11, 2025·7 min read

New Map Reveals First Steps of Protein Clumping in Alzheimer’s

Scientists have mapped how over 140,000 mutations affect the formation of amyloid beta fibrils, offering an unprecedented look at early events in Alzheimer’s disease. By combining DNA synthesis, genetically engineered yeast, and machine learning, they built a detailed energy landscape of the protein’s transition state—an elusive moment before plaque formation begins.

Featured Neurology Neuroscience Psychology

·June 10, 2025·5 min read

Late-Life Mood Disorders May Foreshadow Alzheimer’s

Late-life depression and bipolar disorder may be more than psychiatric conditions—they could be early warning signs of neurodegenerative diseases like Alzheimer’s. Using advanced brain imaging and postmortem tissue analysis, researchers found that half of the participants with late-onset mood disorders showed signs of tau accumulation, a key hallmark of neurodegeneration.

Featured Genetics Neurology Neuroscience

·June 5, 2025·7 min read

HIV Drugs Linked to Lower Alzheimer’s Risk

FDA-approved HIV drugs targeting reverse transcriptase (RT) may reduce Alzheimer’s risk by blocking similar enzymatic activity in the aging brain. Scientists discovered unexpected RT activity in neurons of healthy and Alzheimer’s brains, tracing it to truncated LINE1 elements—ancient genetic sequences capable of copying themselves via RT.

Featured Genetics Neurology Neuroscience

·June 2, 2025·6 min read

Blocking Brain Inflammation Molecule May Halt Alzheimer’s

A new study has uncovered a surprising culprit in the progression of Alzheimer’s disease: the immune molecule STING. Scientists found that STING, normally involved in defending the brain, becomes hyperactive with age, causing harmful inflammation and accelerating brain damage.

Featured Neurology Neuroscience

·May 30, 2025·4 min read

SSRIs Restore Brain Function in Alzheimer’s

A new study suggests that SSRIs, commonly prescribed antidepressants, may reduce biological markers of Alzheimer’s disease. In a cohort of 191 individuals, AD patients on SSRIs had lower levels of plasma phosphorylated tau-181, a key indicator of disease severity.

This shows a man, a woman, DNA, and a brain.

Featured Genetics Neurology Neuroscience

·May 30, 2025·5 min read

Common Gene Variant Doubles Dementia Risk, But Only in Men

New research reveals that men who carry two copies of a common genetic variant in the HFE gene are more than twice as likely to develop dementia, while women with the same variant are not affected. The variant, known as H63D, is linked to haemochromatosis and is present in about 1 in 36 people.

Featured Neurology Neuroscience

·May 29, 2025·6 min read

Sleep Aid May Protect Brain from Alzheimer’s Damage

A common sleep medication, lemborexant, may do more than promote rest—it appears to reduce harmful tau buildup and protect the brain from neurodegeneration in mouse models of Alzheimer’s disease. Researchers found that this orexin receptor antagonist not only restored healthier sleep patterns but also preserved brain structure and reduced inflammation.

Featured Neurology Neuroscience

·May 25, 2025·4 min read

Dementia Diagnoses Decline, But More Are Living Longer With the Disease

A new study of over 25 million Medicare recipients found that while dementia incidence in the U.S. is declining, more older adults are living longer with the condition. From 2015 to 2021, new diagnoses dropped from 3.5% to 2.8%, yet prevalence increased to nearly 12%.

Featured Neurology Neuroscience

·May 21, 2025·4 min read

New Alzheimer’s Drug Boosts Brain Protection, Restores Memory

Researchers have identified a promising drug candidate, DDL-357, that improves memory in Alzheimer’s mouse models by increasing levels of a protective brain protein called clusterin (CLU). CLU helps prevent the buildup of toxic amyloid-beta plaques and tau proteins, both key drivers of Alzheimer’s disease.

Featured Neurology Neuroscience

·May 21, 2025·4 min read

Cold Sore Virus Linked to Alzheimer’s, Antivirals May Lower Risk

A large study suggests that symptomatic infection with herpes simplex virus 1 (HSV-1)—best known for causing cold sores—may significantly raise the risk of developing Alzheimer’s disease. Researchers found that people with HSV-1 were 80% more likely to have Alzheimer’s, while those treated with antiviral medications had a 17% lower risk.

This shows an older man sitting and brains.

Featured Genetics Neurology Neuroscience

·May 18, 2025·4 min read

Sitting for Hours May Shrink the Brain

Prolonged sedentary behavior in adults over 50 is linked to cognitive decline and brain shrinkage in regions vulnerable to Alzheimer’s disease. Even among those who exercise regularly, spending more time sitting was associated with worse cognitive outcomes.

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Alzheimer’s disease

Exercise Rewires Alzheimer’s-Affected Brain Cells

New Map Reveals First Steps of Protein Clumping in Alzheimer’s

Late-Life Mood Disorders May Foreshadow Alzheimer’s

HIV Drugs Linked to Lower Alzheimer’s Risk

Blocking Brain Inflammation Molecule May Halt Alzheimer’s

SSRIs Restore Brain Function in Alzheimer’s

Common Gene Variant Doubles Dementia Risk, But Only in Men

Sleep Aid May Protect Brain from Alzheimer’s Damage

Dementia Diagnoses Decline, But More Are Living Longer With the Disease

New Alzheimer’s Drug Boosts Brain Protection, Restores Memory

Cold Sore Virus Linked to Alzheimer’s, Antivirals May Lower Risk

Sitting for Hours May Shrink the Brain

Brain Conductors Find Precise Connection to Target Cells via Protein Handshake

Multilingualism Calculator Reveals True Language Strengths

Brain Blends Fast and Slow Signals to Shape Human Thought

Immune Signal Ratio May Predict Progressive Multiple Sclerosis

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