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          AgRP

          This shows a brain.
          FeaturedNeurologyNeuroscience
          ·May 16, 2025·5 min read

          Surprising Diabetes Fix Found in the Brain

          New research reveals that hyperactivity in a specific set of brain cells, AgRP neurons in the hypothalamus, plays a key role in type 2 diabetes—independent of obesity. When these neurons were silenced in diabetic mice, blood sugar normalized for months, even without changes in weight or food intake. This challenges long-standing beliefs that obesity and insulin resistance are the sole drivers of diabetes.
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          This shows a brain.
          FeaturedNeuroscience
          ·November 7, 2024·5 min read

          Newly Discovered Brain Neurons May Help Curb Hunger

          Scientists have uncovered a new neuron type, BNC2, which acts quickly to counter hunger-promoting neurons, potentially leading to more effective appetite regulation. These BNC2 neurons, located in the brain’s arcuate nucleus, respond rapidly to hunger cues by inhibiting AGRP neurons responsible for driving appetite. This discovery adds a crucial layer to our understanding of the neural circuits controlling hunger and opens the door for novel treatments for obesity and metabolic conditions.
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          This shows a brain and fatty, sugary foods.
          FeaturedNeuroscience
          ·October 5, 2024·4 min read

          Fat Alone Doesn’t Disrupt Brain’s Appetite Neurons

          A new study reveals that a high-fat diet alone does not appear to be responsible for changes in brain neurons that regulate appetite and energy balance. Researchers found no immediate effect on neurons in the hypothalamus of mice fed a high-fat, low-sugar diet, suggesting that other nutrients like sugar may play a more significant role in altering brain function.
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          This shows neurons in a mouse brain
          FeaturedNeuroscience
          ·June 28, 2022·4 min read

          No More Binge Eating: Signal Pathway in the Brain That Controls Food Intake Discovered

          AgRP neurons in the hypothalamus control the release of endogenous lysophospholipids, helping to control the excitability of cerebral cortex neurons and stimulating the desire for food intake.
          Read More
          This shows a salmon dish
          FeaturedNeuroscience
          ·April 24, 2021·5 min read

          Why Does Food Smell so Good When We’re Hungry?

          A study of hungry mice sheds new light on the neurobiology of olfaction and food attraction. Researchers identified a pathway that promotes attraction to food odors over other olfactory cues.
          Read More
          This is a drawing of a brain and neurons
          FeaturedNeuroscienceOpen Neuroscience ArticlesPsychology
          ·February 11, 2021·6 min read

          Tiny Population of Neurons May Have Big Role in Depression

          Induced changes in the function of AgRP neurons may contribute to depression, researchers report.
          Read More
          This shows a diagram of a mouse brain
          FeaturedNeuroscienceOpen Neuroscience Articles
          ·October 17, 2019·3 min read

          How hunger makes food tastier

          Study identifies the neural circuits that cause hunger-induced increases in the preference for sweet foods and decreased sensitivity to aversive tastes.
          Read More
          FeaturedNeuroscienceOpen Neuroscience Articles
          ·November 15, 2018·4 min read

          Seeing and Smelling Food Prepares the Liver for Digestion: Mouse Study

          Researchers say the sight and smell of food alone may be enough to prompt the liver to start the processes that help digest food.
          Read More
          leptin
          FeaturedGeneticsNeuroscience
          ·April 18, 2018·6 min read

          Leptin’s Neural Circuit Identified

          A new gene editing study reveals how the hormone leptin can help to prevent diabetes and obesity.
          Read More
          Image shows a brain and gut in purple.
          FeaturedNeuroscience
          ·December 5, 2017·6 min read

          Shutting Off Hunger’s Alarm System

          Researchers have identified a mechanism that drives hunger. A new study reports the sight or smell of food can temporarily turn of AgRP neurons, which drive the urge to eat. These neurons remain inactive until the brain receives a signal from the gut that calories have been consumed.
          Read More
          Image shows a brain.
          FeaturedNeuroscience
          ·August 1, 2017·4 min read

          Brain Switch Tells Body to Burn Fat After a Meal

          Researchers report the brain's ability to sense insulin and coordinate feeding with energy expenditure is controlled by a mechanism that is turned on after fasting to inhibit insulin response and conserve energy. After feeding, the mechanism is turned off to facilitate insulin response and expend energy. However, in obese people, researchers believe the switch may stay on all the time.
          Read More
          Image shows a brain with food images in it.
          FeaturedNeuroscience
          ·June 14, 2017·6 min read

          Key Link Between Brain Circuits Governing Hunger and Cravings Revealed

          A new study could help explain how the hungry brain hinders dieting.
          Read More
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          This shows a brain made of sugar cubes, surrounded by sweetener packets.

          Artificial Sweeteners Tied to Faster Cognitive Decline

          This shows a digital brain.

          Humans and AI Share Similar Learning Strategies

          This shows a brain made up of clouds and smoke stacks.

          Air Pollution Linked to Toxic Protein Clumps Driving Lewy Body Dementia

          This shows a mom holding a baby with a clock in the background.

          Breast Milk Has a Built-In Body Clock for Babies

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