Toxic Air Pollution Nanoparticles Found in the Human Brain

Summary: Researchers report they have discovered tiny magnetic nanoparticles from air pollution lodged in the human brain. They believe these nanoparticles could contribute to some cases of Alzheimer’s.

Source: Lancaster University.

Tiny magnetic particles from air pollution have for the first time been discovered to be lodged in human brains– and researchers think they could be a possible cause of Alzheimer’s disease.

Researchers at Lancaster University found abundant magnetite nanoparticles in the brain tissue from 37 individuals aged three to 92-years-old who lived in Mexico City and Manchester. This strongly magnetic mineral is toxic and has been implicated in the production of reactive oxygen species (free radicals) in the human brain, which are associated with neurodegenerative diseases including Alzheimer’s disease.

Professor Barbara Maher, from Lancaster Environment Centre, and colleagues (from Oxford, Glasgow, Manchester and Mexico City) used spectroscopic analysis to identify the particles as magnetite. Unlike angular magnetite particles that are believed to form naturally within the brain, most of the observed particles were spherical, with diameters up to 150 nm, some with fused surfaces, all characteristic of high-temperature formation – such as from vehicle (particularly diesel) engines or open fires.

The spherical particles are often accompanied by nanoparticles containing other metals, such as platinum, nickel, and cobalt.

Professor Maher said: “The particles we found are strikingly similar to the magnetite nanospheres that are abundant in the airborne pollution found in urban settings, especially next to busy roads, and which are formed by combustion or frictional heating from vehicle engines or brakes.”

Image of a brain.

Unlike angular magnetite particles that are believed to form naturally within the brain, most of the observed particles were spherical, with diameters up to 150 nm, some with fused surfaces, all characteristic of high-temperature formation – such as from vehicle (particularly diesel) engines or open fires. NeuroscienceNews.com image is for illustrative purposes only.

Other sources of magnetite nanoparticles include open fires and poorly sealed stoves within homes. Particles smaller than 200 nm are small enough to enter the brain directly through the olfactory nerve after breathing air pollution through the nose.

“Our results indicate that magnetite nanoparticles in the atmosphere can enter the human brain, where they might pose a risk to human health, including conditions such as Alzheimer’s disease,” added Professor Maher.

Leading Alzheimer’s researcher Professor David Allsop, of Lancaster University’s Faculty of Health and Medicine, said: “This finding opens up a whole new avenue for research into a possible environmental risk factor for a range of different brain diseases.”

The results have been published in the paper ‘Magnetite pollution nanoparticles in the human brain’ by the Proceedings of the National Academy of Sciences.

About this neurology research article

The paper’s authors are Barbara Maher, David Allsop, Vassil Karloukovski and Penny Foulds from Lancaster University; Imad Ahmed from the University of Oxford; Donald MacLaren from the University of Glasgow; David Mann from the University of Manchester; Ricardo Torres-Jardon from the Universidad Nacional Autonoma de Mexico; and Lilian Calderon-Garciduenas from The University of Montana.

Source: Lancaster University
Image Source: This NeuroscienceNews.com image is in the public domain.
Video Source: The video is credited to Lancaster University.
Original Research: The study will appear in PNAS during the week of September 5 2016.

Cite This NeuroscienceNews.com Article
Lancaster University. “Toxic Air Pollution Nanoparticles Found in the Human Brain.” NeuroscienceNews. NeuroscienceNews, 6 September 2016.
<http://neurosciencenews.com/neurology-brain-pollution-nanoparticles-4971/>.
Lancaster University. (2016, September 6). Toxic Air Pollution Nanoparticles Found in the Human Brain. NeuroscienceNews. Retrieved September 6, 2016 from http://neurosciencenews.com/neurology-brain-pollution-nanoparticles-4971/
Lancaster University. “Toxic Air Pollution Nanoparticles Found in the Human Brain.” http://neurosciencenews.com/neurology-brain-pollution-nanoparticles-4971/ (accessed September 6, 2016).
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