Bacteria in the Nose May Increase Risk of Alzheimer’s Disease

Summary: Chlamydia pneumoniae, a bacterium that is commonly present in the nose, can invade the brain via nerves in the nasal cavity. Once the bacterium is in the central nervous system, brain cells react within days, depositing Alzheimer’s-associated amyloid-beta peptides.

Source: Griffith University

New research from Griffith University has shown that a bacterium commonly present in the nose can sneak into the brain and set off a cascade of events that may lead to Alzheimer’s disease.

Associate Professor Jenny Ekberg and colleagues from the Clem Jones Centre for Neurobiology and Stem Cell Research at Menzies Health Institute Queensland and Griffith Institute for Drug Discovery, in collaboration with Queensland University of Technology, have discovered that the bacterium Chlamydia pneumoniae can invade the brain via the nerves of the nasal cavity.

While this bacterium often causes respiratory tract infections, it has also been found in the brain which has raised the question of whether it causes damage to the central nervous system.

The research team has performed extensive research in animal models to show not only how the bacteria gets into the brain, but also how it leads to Alzheimer disease pathologies.

“Our work has previously shown that that several different species of bacteria can rapidly, within 24 hours, enter the central nervous system via peripheral nerves extending between the nasal cavity and the brain,” Associate Professor Ekberg said.

“With this background knowledge we were able to track how this new bacterium, Chlamydia pneumoniae can also sneak past the blood-brain barrier and quickly enter the brain.”

The new study shows that once the bacteria are in the central nervous system, the cells of the brain react within days by depositing beta amyloid peptide, which is the hallmark plaque of Alzheimer’s disease.

After several weeks, numerous gene pathways that are known to be involved in Alzheimer’s disease are also dramatically activated.

The research also showed that when the bacteria invade the olfactory nerve, peripheral nerve cells (glial cells), become infected and these cells may be how the bacteria can persist within the nervous system.

“These cells are usually important defenders against bacteria, but in this case, they become infected and can help the bacteria to spread,”‘ Associate Professor Ekberg said.

This shows an older man's face
While this bacterium often causes respiratory tract infections, it has also been found in the brain which has raised the question of whether it causes damage to the central nervous system. Image is in the public domain

“We have suspected for a long time that bacteria, and even viruses, can lead to neuroinflammation and contribute to initiation of Alzheimer’s disease, however, the bacteria alone may not be enough to cause disease in someone. Perhaps it requires the combination of a genetic susceptibility plus the bacteria to lead to Alzheimer’s disease in the long term.

“Now that we have this new evidence, it gives us the drive to urgently find treatments to stop this contributing factor to Alzheimer’s disease.

While the studies were conducted in mice, humans have the same nerves and can be infected by the same bacteria, so the researchers believe the results are translatable to humans.

“We are already working on treatment options. With the Griffith Institute for Drug Discovery, we are identifying potential drugs that can help the glial cells to destroy the bacteria which are already in the brain.

“In addition, Professor Ken Beagley at QUT is working on a vaccine against Chlamydia which may reduce the ability of the pathogen to enter the brain.”

About this Alzheimer’s disease research news

Author: Press Office
Source: Griffith University
Contact: Press Office – Griffith University
Image: The image is in the public domain

Original Research: Open access.
Chlamydia pneumoniae can infect the central nervous system via the olfactory and trigeminal nerves and contributes to Alzheimer’s disease risk” by Anu Chacko et al. Scientific Reports


Abstract

Chlamydia pneumoniae can infect the central nervous system via the olfactory and trigeminal nerves and contributes to Alzheimer’s disease risk

Chlamydia pneumoniae is a respiratory tract pathogen but can also infect the central nervous system (CNS). Recently, the link between C. pneumoniae CNS infection and late-onset dementia has become increasingly evident. In mice, CNS infection has been shown to occur weeks to months after intranasal inoculation.

By isolating live C. pneumoniae from tissues and using immunohistochemistry, we show that C. pneumoniae can infect the olfactory and trigeminal nerves, olfactory bulb and brain within 72 h in mice. C. pneumoniae infection also resulted in dysregulation of key pathways involved in Alzheimer’s disease pathogenesis at 7 and 28 days after inoculation.

Interestingly, amyloid beta accumulations were also detected adjacent to the C. pneumoniae inclusions in the olfactory system. Furthermore, injury to the nasal epithelium resulted in increased peripheral nerve and olfactory bulb infection, but did not alter general CNS infection. In vitro, C. pneumoniae was able to infect peripheral nerve and CNS glia.

In summary, the nerves extending between the nasal cavity and the brain constitute invasion paths by which C. pneumoniae can rapidly invade the CNS likely by surviving in glia and leading to Aβ deposition.

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