Summary: Researchers have identified a gene that allows serotonin neurons to spread their brances throughout the brain. Mice lacking this gene showed entangled neuron branches and signs of depression.
Source: UW Medicine.
Characteristic also is associated with overbite and tuberculosis, investigator notes.
Individuals with a slender lower face are about 25 percent more likely to be left-handed. This unexpected finding was identified in 13,536 individuals who participated in three national surveys conducted in the United States.
This association may shed new light on the origins of left-handedness, as slender jaws have also been associated with susceptibility to tuberculosis, a disease that has shaped human evolution and which today affects 2 billion people.
The finding was published April 26 in the journal Laterality: Asymmetries of Body, Brain and Cognition. The author, Philippe Hujoel, is a professor at the University of Washington School of Dentistry and an adjunct professor of epidemiology at its School of Public Health.
Slender jaws are a common facial feature, affecting about one in five U.S. adolescents. Past U.S. surveys measured the prevalence of this condition by evaluating how the upper and lower teeth come together. People with slender jaws typically have a lower jaw which bites a bit backward, giving them a convex facial profile and what’s commonly called an overbite.
“Almost 2,000 years ago a Greek physician was first to identify slender jaws as a marker for TB susceptibility, and he turned out to be right!” Hujoel said. “Twentieth-century studies confirmed his clinical observations, as slender facial features became recognized as one aspect of a slender physique of a TB-susceptible person. The low body weight of this slender physique is still today recognized by the Centers for Disease Control and Prevention as a marker for TB susceptibility.”
He said the finding raises the hypothesis that the genetics that shape facial features and tuberculosis susceptibility also increase the likelihood for left-handedness.
Such a hypothesis may explain curious geographical coincidences. For example, the United Kingdom was described as the tuberculosis capital of Western Europe, and has a high prevalence of left-handedness and people with slender faces. Other populations, such as the Eskimos, were in the 19th century described as tuberculosis-resistant, having robust facial features, and typically depicted in art as showing right-hand dominance with tools and instruments.
Whether this is more than a coincidence needs further exploration, Hujoel said.
In the early 20th century, slender individuals were described as “ectomorphs” – a term that persists in popular culture as a reference to dieting and bodybuilding, Hujoel noted.
“In a world dominated by an obesity crisis and right-handers, ectomorphs can be different in their desires,” he said. “Popular websites suggest they commonly express a desire to gain weight or muscle mass. Their slightly increased chance of being a ‘leftie’ is an additional feature that makes them different.”
About this neuroscience research article
Source: Brian Donohue – UW Medicine Image Source: NeuroscienceNews.com image is credited to Philippe Hujoel. Original Research:Abstract for “Handedness and lower face variability: Findings in three national surveys” by Philippe P. Hujoel in Laterality: Asymmetries of Body, Brain and Cognition. Published online April 26 2017 doi:10.1080/1357650X.2017.1317265
Cite This NeuroscienceNews.com Article
[cbtabs][cbtab title=”MLA”]UW Medicine “Facial Bone Structure A Novel Marker for Left-Handedness.” NeuroscienceNews. NeuroscienceNews, 27 April 2017. <https://neurosciencenews.com/left-handedness-bone-structure-6528/>.[/cbtab][cbtab title=”APA”]UW Medicine (2017, April 27). Facial Bone Structure A Novel Marker for Left-Handedness. NeuroscienceNew. Retrieved April 27, 2017 from https://neurosciencenews.com/left-handedness-bone-structure-6528/[/cbtab][cbtab title=”Chicago”]UW Medicine “Facial Bone Structure A Novel Marker for Left-Handedness.” https://neurosciencenews.com/left-handedness-bone-structure-6528/ (accessed April 27, 2017).[/cbtab][/cbtabs]
Handedness and lower face variability: Findings in three national surveys
Lower face variability in modern humans has been associated with a series of phenotypic characteristics including body architecture and handedness. The aim of this study was to provide a systematic review of lower face variability and handedness in national health surveys conducted in the United States. Three informative surveys with a total of 13,663 participants were identified. Lower face variability was described as one of six facial phenotypes and related to handedness using logistic regression models while adjusting for sex, ancestry, geography, and income. The results on 13,536 participants with complete information showed that bilateral retrognathism—a marker for a lower face phenotype characterized by a convex facial profile and slender jaws—was associated with a 25% increased odds for non-right-handedness (odds ratio, 1.250; 95% confidence interval: 1.076–1.453, p-value < .004). This association between non-right-handedness and a convex facial profile may unexpectedly find its origin in the genetic polymorphisms which determine tuberculosis susceptibility.
“Handedness and lower face variability: Findings in three national surveys” by Philippe P. Hujoel in Laterality: Asymmetries of Body, Brain and Cognition. Published online April 26 2017 doi:10.1080/1357650X.2017.1317265