Females Found to Itch Less Than Males

Summary: The female hormone estradiol helps suppress itch associated with psoriasis. The findings shed light on why men are more prone to psoriasis and offers hope for new targeted treatment for itch disorders.

Source: Kyoto University

Among the many reasons men may have for envying women, at least when it comes to skin inflammation, is that women have a significantly lower incidence of severe psoriasis. However, the underlying reason for the sex differences had been unclear.

Now, a team of researchers has found that the female hormone estradiol suppresses psoriasis, and the protective role of the hormone has provided a basis for its therapeutic potential.

“Our results have not only revealed the molecular mechanisms of sex differences in psoriasis but also shed new light on our understanding of the physiological role of estradiol,” says Hamamatsu University School of Medicine’s Tetsuya Honda, formerly of Kyoto University.

The team tested conditional knockout mice, or cko mice, with ovaries removed but supplemented with estradiol pellets or a placebo. In contrast to wild-type mice, the cko mice without the natural ovarian hormones estradiol showed symptoms of severe skin inflammation.

This shows an inflammation map of a female body
Skin inflammation was found in the absence of ovarian estradiol in mice. Credit: KyotoU/Global Comms

Once these mice were given estradiol, the production of IL-17A and IL-1β cytokines in neutrophil and macrophage immune cells was reversed, reducing the inflammation. This effect was also observed in human neutrophils in vitro.

What intrigued the researchers was how the lack of estrogen receptors in immune cells made estradiol ineffective against the cytokines.

“These results indicate that estradiol suppresses psoriatic inflammation by regulating neutrophil and macrophage cells,” concludes the author.

About this neuroscience research news

Author: Press Office
Source: Kyoto University
Contact: Press Office – Kyoto University
Image: The image is credited to Kyoto University

Original Research: Closed access.
Estradiol suppresses psoriatic inflammation in mice by regulating neutrophil and macrophage functions” by Akimasa Adachi et al. Journal of Allergy and Clinical Immunology


Estradiol suppresses psoriatic inflammation in mice by regulating neutrophil and macrophage functions


Psoriasis is a common inflammatory skin disease resulting from dysregulation of the IL-23/TH17 immune axis. The prevalence and severity of psoriasis is higher in men than in women, although the underlying reasons for this are unclear.


We studied whether estradiol, a female hormone, plays protective roles in imiquimod-induced psoriatic inflammation in mice by regulating neutrophil and macrophage functions.


Wild-type mice and conditional knockout mice were ovariectomized, supplemented with placebo or estradiol pellets, and an imiquimod-containing cream applied.


Mice without endogenous ovarian hormones exhibited exacerbated psoriatic inflammation including increased production of IL-17A and IL-1β, which was reversed by exogenously added estradiol. The suppressive effect of estradiol on the production of IL-1β and IL-17A was abolished in mice lacking estrogen receptors in neutrophils and macrophages (Esr1f/fEsr2f/fLysM-Cre+ mice). IL-1β, which is required for production of IL-17A in the psoriasis model, was mainly produced by neutrophils and inflammatory macrophages. Estradiol suppressed IL-1β production from neutrophils and macrophages in mice both in vivo and in vitro and from human neutrophils in vitro.


Our results suggest a novel mechanism for sex-dependent differences in psoriasis clinical phenotypes that may shed new light on the pathology of psoriasis.

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  1. Latex seems to be overlooked as the most common cause of skin itching.. I had first hand experience with the horrors of latex.. I was a homecleaner who started using latex gloves to protect myself from cleaning chemicals for years till I got attacked from latex that crawled under skin . It was a horrible experience.. I healed …but latex sensitivity still remains with me.. I start using Crocs after making sure that it was not made of latex . I loved Crocs till recently when I got same latex attacks all voer again in different ways . I never suspected my Crocs till I stopped wearing Crocs. I healed.
    I think that people has varying tolerances from minor itches to all bombed out itchings that nearly killed me!
    Lesson learned and shared here! thank you! I misssed Crocs , though!
    In other senses, if it is latex attack.. dont buy hand/body lotions as it wont work! Latex is not responsive to lotions at all whatsoever.. it gets under your damn skin and drives you insane!
    I tried inner orange peels fresh to rub my affected skin and it works like a god miracle, trust me. I had skin blisters all over me! Wow scary! as …

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